Pharmacokinetics and Plasma Cellular Antioxidative Effects of Flavanols After Oral Intake of Green Tea Formulated with Vitamin C and Xylitol in Healthy Subjects

Abstract

This study aimed to test whether green tea formulated with vitamin C and xylitol (GTVX) could improve absorption of flavanols and total antioxidant activity (TAC) of plasma compared with green tea only (GT) in healthy subjects. The total radical-trapping antioxidant parameter method was used to measure the TAC of plasma. C-max, T-max, and area under the curve (AUC) of flavanols in plasma after consumption of GTVX were 5980.58g/mL, 2.14h, and 18,915.56hg/mL, respectively, indicating that GTVX showed significantly higher AUC than GT (13,855.43g/mL). The peak TACs occurred at 3 and 0.5h after intake of GT and GTVX, respectively. The TAC of plasma was found to be significantly higher in GTVX than in GT at each time point. This study suggests that formulating green tea with vitamin C and xylitol could increase the absorption of flavanols in green tea, enhancing cellular antioxidative effects.