가시오가피 열매 추출물이 유방암 세포주에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황종현 | - |
dc.contributor.author | 김승만 | - |
dc.contributor.author | 황귀서 | - |
dc.contributor.author | 전찬용 | - |
dc.contributor.author | 강기성 | - |
dc.date.accessioned | 2022-10-21T02:40:12Z | - |
dc.date.available | 2022-10-21T02:40:12Z | - |
dc.date.created | 2022-10-21 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1226-9174 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85810 | - |
dc.description.abstract | Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of a water extract of Acanthopanax senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231). Methods: The MTT assay was used to assess cell proliferation. The expression of apoptosis-related genes was assessed by quantitative real-time PCR. Results: ASF treatment caused a dose-dependent inhibition of cell growth in both estrogen-independent MDA-MB-231 and estrogen-dependent MCF-7 breast cancer cells. ASF decreased mRNA expression of the apoptotic suppressor gene Bcl-xL, and increased mRNA expression of proapoptotic genes. ASF increased the mRNA expression of p21 and RIP-1 in both cell types. ASF decreased the mRNA expression of survivin in the MCF-7 cell line. Conclusions: ASF exhibits anti-cancer activity involving apoptotic cell death. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한한방내과학회 | - |
dc.relation.isPartOf | 대한한방내과학회지 | - |
dc.title | 가시오가피 열매 추출물이 유방암 세포주에 미치는 영향 | - |
dc.title.alternative | Effect of Extract of Acanthopanax Senticosus Fruit on Breast Cancer Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.22246/jikm.2022.43.4.529 | - |
dc.identifier.bibliographicCitation | 대한한방내과학회지, v.43, no.4, pp.529 - 541 | - |
dc.identifier.kciid | ART002887677 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 541 | - |
dc.citation.startPage | 529 | - |
dc.citation.title | 대한한방내과학회지 | - |
dc.citation.volume | 43 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | 황종현 | - |
dc.contributor.affiliatedAuthor | 김승만 | - |
dc.contributor.affiliatedAuthor | 황귀서 | - |
dc.contributor.affiliatedAuthor | 전찬용 | - |
dc.contributor.affiliatedAuthor | 강기성 | - |
dc.subject.keywordAuthor | Acanthopanax senticosus | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | MCF-7 | - |
dc.subject.keywordAuthor | MDA-MB-231 | - |
dc.description.journalRegisteredClass | kci | - |
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