Differences in mGluR5 Availability Depending on the Level of Social Avoidance in Drug-Naive Young Patients with Major Depressive Disorder
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeong-Hee | - |
dc.contributor.author | Joo, Yo-Han | - |
dc.contributor.author | Son, Young-Don | - |
dc.contributor.author | Kim, Hang-Keun | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.date.accessioned | 2022-10-24T05:40:06Z | - |
dc.date.available | 2022-10-24T05:40:06Z | - |
dc.date.created | 2022-10-24 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1176-6328 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85842 | - |
dc.description.abstract | Background: Previous research has shown that metabotropic glutamate receptor-5 (mGluR5) signaling is significantly involved in social avoidance. We investigated the relationship between levels of social avoidance and mGluR5 availability in drug-naive young patients with major depressive disorder (MDD). Methods: Twenty non-smoking patients and eighteen matched non-smoking healthy controls underwent [C-11]ABP688 positron emission tomography (PET) and magnetic resonance imaging scans. The binding potential (BPND) of [C-11]ABP688 was obtained using the simplified reference tissue model. Patients' level of social avoidance was assessed using the Social Avoidance and Distress Scale (SADS). For [C-11]ABP688 BPND, the region-of-interest (ROI)-based between-group comparisons and correlations with SADS scores were investigated. The frontal cortices were chosen as a priori ROIs based on previous PET investigations in MDD, and on literature underscoring the importance of the frontal cortex in social avoidance. Results: Independent samples t-tests revealed no significant differences in [C-11]ABP688 BPND in the frontal cortices between the MDD patient group as a whole and healthy controls. One-way analysis of variance with post-hoc tests revealed significantly lower BPND in the bilateral superior frontal cortex (SFC) and left middle frontal cortex (MFC) in MDD patients with low levels of social avoidance (L-SADS) than in healthy controls. The L-SADS patients also had significantly lower BPND in the medial part of the right SFC than both MDD patients with high levels of social avoidance (H-SADS) and healthy controls. The L-SADS patients also showed significantly lower BPND in the orbital parts of the SFC, MFC, and inferior frontal cortex than H-SADS patients. No significant group differences were found between H- SADS patients and healthy controls. The ROI-based correlation analysis revealed significant positive correlations between social avoidance levels and frontal [C-11]ABP688 BPND in the entire patients. Conclusion: Our exploratory study shows significant differences in frontal mGluR5 availability depending on the level of social avoidance in drug-naive non-smoking MDD patients, suggesting that social avoidance should be considered as one of the clinical factors involved in mGluR5 signaling changes in depression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | NEUROPSYCHIATRIC DISEASE AND TREATMENT | - |
dc.title | Differences in mGluR5 Availability Depending on the Level of Social Avoidance in Drug-Naive Young Patients with Major Depressive Disorder | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000859351400001 | - |
dc.identifier.doi | 10.2147/NDT.S379395 | - |
dc.identifier.bibliographicCitation | NEUROPSYCHIATRIC DISEASE AND TREATMENT, v.18, pp.2041 - 2053 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85137865196 | - |
dc.citation.endPage | 2053 | - |
dc.citation.startPage | 2041 | - |
dc.citation.title | NEUROPSYCHIATRIC DISEASE AND TREATMENT | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Kim, Jeong-Hee | - |
dc.contributor.affiliatedAuthor | Joo, Yo-Han | - |
dc.contributor.affiliatedAuthor | Son, Young-Don | - |
dc.contributor.affiliatedAuthor | Kim, Hang-Keun | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | social avoidance | - |
dc.subject.keywordAuthor | metabotropic glutamate receptor-5 | - |
dc.subject.keywordAuthor | positron emission tomography | - |
dc.subject.keywordAuthor | [C-11]ABP688 | - |
dc.subject.keywordAuthor | major depressive disorder | - |
dc.subject.keywordPlus | GLUTAMATE-RECEPTOR 5 | - |
dc.subject.keywordPlus | IN-VIVO VARIATION | - |
dc.subject.keywordPlus | ANTIDEPRESSANT-LIKE | - |
dc.subject.keywordPlus | ANXIOLYTIC-LIKE | - |
dc.subject.keywordPlus | FEAR | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordPlus | PHOBIA | - |
dc.subject.keywordPlus | EXTINCTION | - |
dc.subject.keywordPlus | ANXIETY | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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