Oddioside A, a New Phenolic Glycoside Isolated from the Fruits of Morus alba (Mulberry), Protects TNF-alpha-Induced Human Dermal Fibroblast Damage
DC Field | Value | Language |
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dc.contributor.author | Kim, Kang Sub | - |
dc.contributor.author | Kim, Ranhee | - |
dc.contributor.author | Son, So-Ri | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Jang, Dae Sik | - |
dc.contributor.author | Lee, Sullim | - |
dc.date.accessioned | 2022-11-11T00:40:06Z | - |
dc.date.available | 2022-11-11T00:40:06Z | - |
dc.date.created | 2022-11-08 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86000 | - |
dc.description.abstract | In our preliminary study, a hot water extract from the fruits of Morus alba (mulberry) inhibited the secretion of metalloproteinase-1 (MMP-1) against tumor necrosis factor-alpha (TNF-alpha)-stimulated human dermal fibroblasts (HDFs), and therefore we researched its active compounds. In the present study, a new phenolic glycoside (oddioside A, 1) and 21 known compounds (2-22) were isolated from the hot water extract from the fruits of M. alba by repeated chromatography. The chemical structure of the new compound 1 was elucidated by its spectroscopic data (1D- and 2D-NMR and HRMS) measurement and by acidic hydrolysis. The presence of sargentodoside E (2), eugenyl glucoside (6), 2-O-beta-D-glucopyranosyl-4,6-dihydroxybenzaldehyde (7), 7S,8R-erythro-7,9,9'-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan-4-O-beta-D-glucopyranoside (11), pinoresinol-4-O-beta-D-glucopyranoside (12), taxifolin-7-O-beta-D-glucopyranoside (20), and pinellic acid (21) were reported from M. alba for the first time in this study. The new compound oddioside A (1) suppressed the secretion of MMP-1 and increased collagen in TNF-alpha-stimulated HDFs. In addition, the phosphorylation of mitogen-activated protein kinases (MAPKs) was inhibited by oddioside A. In conclusion, the extract from fruits of M. alba and its constituent oddioside A may be a potential agent to prevent inflammation-related skin aging and other skin disorders. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | ANTIOXIDANTS | - |
dc.title | Oddioside A, a New Phenolic Glycoside Isolated from the Fruits of Morus alba (Mulberry), Protects TNF-alpha-Induced Human Dermal Fibroblast Damage | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000872124900001 | - |
dc.identifier.doi | 10.3390/antiox11101894 | - |
dc.identifier.bibliographicCitation | ANTIOXIDANTS, v.11, no.10 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85140482894 | - |
dc.citation.title | ANTIOXIDANTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Kim, Kang Sub | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.contributor.affiliatedAuthor | Lee, Sullim | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | human dermal fibroblasts | - |
dc.subject.keywordAuthor | tumor necrosis factor-alpha | - |
dc.subject.keywordAuthor | skin damage | - |
dc.subject.keywordAuthor | Morus alba | - |
dc.subject.keywordAuthor | phenolic glycoside | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY ACTIVITIES | - |
dc.subject.keywordPlus | CHRONIC INFLAMMATION | - |
dc.subject.keywordPlus | MEDICINAL-PLANTS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | ISOQUERCITRIN | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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