Sodium salicylate induces browning of white adipocytes via M2 macrophage polarization by HO-1 upregulation
DC Field | Value | Language |
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dc.contributor.author | Choi, Hye-Eun | - |
dc.contributor.author | Jeon, Eun Jeong | - |
dc.contributor.author | Kim, Dong Young | - |
dc.contributor.author | Choi, Mi Jin | - |
dc.contributor.author | Yu, Hana | - |
dc.contributor.author | Kim, Jea Il | - |
dc.contributor.author | Cheon, Hyae Gyeong | - |
dc.date.accessioned | 2022-11-21T00:40:04Z | - |
dc.date.available | 2022-11-21T00:40:04Z | - |
dc.date.created | 2022-09-04 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86130 | - |
dc.description.abstract | Browning, a white to brown-like (beige) adipocyte conversion, offers a promising therapeutic strategy for the treatment of human obesity. In the present study, the effects of sodium salicylate, a nonsteroidal anti-inflammatory drug, on adipocyte browning were investigated. We found sodium salicylate altered the macrophage phenotype to M2 in RAW264.7 cells, mediated by up-regulation of heme oxygenase-1 (HO-1), and sodium salicylate-treated conditioned medium from macrophages (Sal-M2 CM) induced browning of fully differentiated 3T3-L1 adipocytes. Conversely, the conditioned medium obtained from macrophages when treated with sodium salicylate in the presence of either ZnPP (a HO-1 inhibitor) or HO-1 siRNA did not induce browning. In association with macrophage HO-1 induction by sodium salicylate, iron production also increased, and deferoxamine (an iron chelator) blunted the browning effects of Sal-M2 CM, suggesting that iron may play a role in the Sal-M2 CM-induced browning. The in vivo browning effects of sodium salicylate were confirmed in ob/ob mice, whereas in vivo macrophage depletion by clodronate as well as HO-1 blockade by either ZnPP or adeno-associated virus carrying HO-1 shRNA (AAV–HO–1 shRNA) attenuated the browning effects of sodium salicylate. These results reveal sodium salicylate induces browning in vitro and in vivo by up-regulating HO-1 thus promoting M2 polarization. © 2022 Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | European Journal of Pharmacology | - |
dc.title | Sodium salicylate induces browning of white adipocytes via M2 macrophage polarization by HO-1 upregulation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000881238200004 | - |
dc.identifier.doi | 10.1016/j.ejphar.2022.175085 | - |
dc.identifier.bibliographicCitation | European Journal of Pharmacology, v.928 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85132538065 | - |
dc.citation.title | European Journal of Pharmacology | - |
dc.citation.volume | 928 | - |
dc.contributor.affiliatedAuthor | Choi, Hye-Eun | - |
dc.contributor.affiliatedAuthor | Jeon, Eun Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Dong Young | - |
dc.contributor.affiliatedAuthor | Choi, Mi Jin | - |
dc.contributor.affiliatedAuthor | Yu, Hana | - |
dc.contributor.affiliatedAuthor | Kim, Jea Il | - |
dc.contributor.affiliatedAuthor | Cheon, Hyae Gyeong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Browning | - |
dc.subject.keywordAuthor | Heme oxygenase-1 | - |
dc.subject.keywordAuthor | M2 polarization | - |
dc.subject.keywordAuthor | Salicylate | - |
dc.subject.keywordPlus | ALTERNATIVELY ACTIVATED MACROPHAGES | - |
dc.subject.keywordPlus | INDUCED INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | BEIGE | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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