Bone Regeneration with 3D-Printed Hybrid Bone Scaffolds in a Canine Radial Bone Defect Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yoon Jae | - |
dc.contributor.author | Ryu, Yeon Hee | - |
dc.contributor.author | Lee, Su Jin | - |
dc.contributor.author | Moon, Suk-Ho | - |
dc.contributor.author | Kim, Ki Joo | - |
dc.contributor.author | Jin, Byeong Ju | - |
dc.contributor.author | Lee, Kyoung-Don | - |
dc.contributor.author | Park, Jung Kyu | - |
dc.contributor.author | Lee, Jin Woo | - |
dc.contributor.author | Lee, Seung-Jae | - |
dc.contributor.author | Jeong, Hun-Jin | - |
dc.contributor.author | Rhie, Jong Won | - |
dc.date.accessioned | 2022-11-25T00:40:06Z | - |
dc.date.available | 2022-11-25T00:40:06Z | - |
dc.date.created | 2022-11-08 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86146 | - |
dc.description.abstract | Background: The repair of large bone defects remains a significant challenge in clinical practice and requires bone grafts or substitute materials. In this study, we developed a unique hybrid bone scaffold comprising a three dimensional (3D)-printed metal plate for weight bearing and a biodegradable polymer tube serving as bone conduit. We assessed the long-term effect of the hybrid bone scaffold in repairing radial bone defects in a beagle model. Methods: Bone defects were created surgically on the radial bone of three beagle dogs and individually-tailored scaffolds were used for reconstruction with or without injection of autologous bone and decellularized extracellular matrix (dECM). The repaired tissue was evaluated by X-ray, micro-computed tomography, and histological observation 6 months after surgery. The functional integrity of hybrid bone scaffold-mediated reconstructions was assessed by gait analysis. Results: In vivo analysis showed that the hybrid bone scaffolds maintained the physical space and bone conductivity around the defect. New bone was formed adjacent to the scaffolds. Addition of autologous bone and dECM in the polymer tube improved healing by enhancing bone induction and osteoconduction. Furthermore, the beagles' gait appeared normal by 4 months. Conclusion: The future of bone healing and regeneration is closely related to advances in tissue engineering. Bone production using autologous bone and dECM loaded on 3D-printed hybrid bone scaffolds can successfully induce osteogenesis and provide mechanical force for functional bone regeneration, even in large bone defects. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | - |
dc.relation.isPartOf | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.title | Bone Regeneration with 3D-Printed Hybrid Bone Scaffolds in a Canine Radial Bone Defect Model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000859887800001 | - |
dc.identifier.doi | 10.1007/s13770-022-00476-y | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.19, no.6, pp.1337 - 1347 | - |
dc.identifier.kciid | ART002903180 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85142298631 | - |
dc.citation.endPage | 1347 | - |
dc.citation.startPage | 1337 | - |
dc.citation.title | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 19 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Park, Jung Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Jin Woo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.subject.keywordAuthor | Bone abnormalities | - |
dc.subject.keywordAuthor | Tissue engineering | - |
dc.subject.keywordAuthor | Tissue scaffolds | - |
dc.subject.keywordAuthor | 3D printing | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | REPAIR | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.