Astaxanthin Ameliorates Atopic Dermatitis by Inhibiting the Expression of Signal Molecule NF-kB and Inflammatory Genes in Mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Donghwan | - |
dc.contributor.author | Kim, Yong-Suk | - |
dc.contributor.author | Song, Ho Sueb | - |
dc.date.accessioned | 2022-12-01T01:40:13Z | - |
dc.date.available | 2022-12-01T01:40:13Z | - |
dc.date.created | 2022-12-01 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 2586-288X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86183 | - |
dc.description.abstract | Background: This study was conducted to determine the anti-inflammatory effect of astaxanthin, on atopic dermatitis.Methods: Changes in mouse body weight, lymph node weight, and the degree of improvement in symptoms were measured to determine the inflammatory response. Real-time reverse transcription-polymerase chain reaction tests were performed to determine the degree of expression of inflammation-related cytokines (IL-31 and IL-33 and chemokines such as CCL17 and CCL22), and western blot analysis was performed to evaluate the expression of inflammation-related factors (iNOS, COX-2, and NF-kB signaling molecules p-IkBα, p50, p-65 and pSTAT3).Results: The degree of symptoms significantly improved in the PA+AX group. Lymph node weight in the PA+AX group was lower than the PA group. Inflammatory cytokines (IL-31, IL-33, and inflammatory chemokines such as CCL17 and CCL22) were significantly reduced in the PA+AX group compared with the PA group. The expression of inflammatory genes (iNOS, COX-2, NF-kB and signaling molecules (p-IkBα, p50, p65, and p-STAT 3) was lower in the PA+AX group compared with the PA group.Conclusion: Astaxanthin may modulate the inflammatory response in a mouse model of atopic dermatitis and has an anti-inflammatory effect. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한침구의학회 | - |
dc.relation.isPartOf | Journal of Acupuncture Research | - |
dc.title | Astaxanthin Ameliorates Atopic Dermatitis by Inhibiting the Expression of Signal Molecule NF-kB and Inflammatory Genes in Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.13045/jar.2022.00255 | - |
dc.identifier.bibliographicCitation | Journal of Acupuncture Research, v.39, no.4, pp.304 - 309 | - |
dc.identifier.kciid | ART002900236 | - |
dc.description.isOpenAccess | Y | - |
dc.citation.endPage | 309 | - |
dc.citation.startPage | 304 | - |
dc.citation.title | Journal of Acupuncture Research | - |
dc.citation.volume | 39 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Song, Ho Sueb | - |
dc.subject.keywordAuthor | astaxanthin | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | NF-kB | - |
dc.description.journalRegisteredClass | kci | - |
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