Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease
DC Field | Value | Language |
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dc.contributor.author | Yang, Dong Joo | - |
dc.contributor.author | Leec, Kyung Suk | - |
dc.contributor.author | Ko, Chang Mann | - |
dc.contributor.author | Moh, Sang Hyun | - |
dc.contributor.author | Song, Jihyeok | - |
dc.contributor.author | Hur, Lucia C. | - |
dc.contributor.author | Cheon, Young Woo | - |
dc.contributor.author | Yang, Seung Ho | - |
dc.contributor.author | Choi, Yun-Hee | - |
dc.contributor.author | Kim, Ki Woo | - |
dc.date.available | 2020-02-28T03:41:04Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8629 | - |
dc.description.abstract | The skin responds to environmental stressors by coordinated actions of neuropeptides and their receptors. An endogenous peptide for delta-opioid receptor (DOPr), Leu-enkephalin (L-ENK), is expressed in the skin and its expression is altered in pathological conditions. Although the importance of DOPr is rapidly gaining recognition, the molecular mechanisms underlying its effects on wound healing are largely undefined. We show here that L-ENK induced activation of Erk, P90(RSK) and Elk-1 and promoted the disruption of hemidesmosomes and the expression of matrix metalloprotease (MMP)-2 and MMP-9, important processes for wound healing. Treatment with Erk inhibitor blocked activation of P90(RSK) and Elk-1 and significantly blunted wound repair. Therefore, our results suggest that activation of Erk and its downstream effectors, P90(RSK) and Elk-1, are critical for DOPr-mediated skin homeostasis. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | PEPTIDES | - |
dc.subject | MU-OPIATE RECEPTOR | - |
dc.subject | DELTA-OPIOID RECEPTOR | - |
dc.subject | BETA-ENDORPHIN | - |
dc.subject | HUMAN EPIDERMIS | - |
dc.subject | CELL-MIGRATION | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | IN-VITRO | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | HUMAN KERATINOCYTES | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.title | Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000369597900007 | - |
dc.identifier.doi | 10.1016/j.peptides.2015.12.010 | - |
dc.identifier.bibliographicCitation | PEPTIDES, v.76, pp.57 - 64 | - |
dc.identifier.scopusid | 2-s2.0-84954289890 | - |
dc.citation.endPage | 64 | - |
dc.citation.startPage | 57 | - |
dc.citation.title | PEPTIDES | - |
dc.citation.volume | 76 | - |
dc.contributor.affiliatedAuthor | Cheon, Young Woo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | delta-Opioid receptor | - |
dc.subject.keywordAuthor | Leucine-enkephalin | - |
dc.subject.keywordAuthor | Wound healing | - |
dc.subject.keywordAuthor | Hemidesmosome | - |
dc.subject.keywordPlus | MU-OPIATE RECEPTOR | - |
dc.subject.keywordPlus | DELTA-OPIOID RECEPTOR | - |
dc.subject.keywordPlus | BETA-ENDORPHIN | - |
dc.subject.keywordPlus | HUMAN EPIDERMIS | - |
dc.subject.keywordPlus | CELL-MIGRATION | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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