Safety of using Escherichia coli bacteriophages as a sanitizing agent based on inflammatory responses in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Ji-Yeon | - |
dc.contributor.author | Kim, Jung-Eun | - |
dc.contributor.author | Song, Yoon-Jae | - |
dc.contributor.author | Park, Jong-Hyun | - |
dc.date.available | 2020-02-28T03:41:09Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8634 | - |
dc.description.abstract | Use of bacteriophages as sanitizing agents has received much attention. However, safety in humans is debatable. To determine inflammatory immune responses against bacteriophages, rats were treated with a 8 log plaque-forming cocktail of 5 bacteriophages for pathogenic Escherichia coli per day for 4 weeks. Food consumption, feeding efficiency, and body weight of rats treated with the cocktail were not different from controls. Phages were not detected in the sera of phage-fed rats with no changes in organ weights. Notable changes were not observed upon histopathological examination of the liver, kidney, and spleen. Pro-inflammatory cytokine mRNA expression, except COX-2 (2.4x increase), remained unaffected after treatment with the phage cocktail. No remarkable changes were observed for levels of 12 pro-inflammatory cytokines in sera. Inflammatory responses in rats orally treated with a phage cocktail were not observed. Bacteriophages for E. coli are indicated as immunologically safe in rats. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.title | Safety of using Escherichia coli bacteriophages as a sanitizing agent based on inflammatory responses in rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000370349900050 | - |
dc.identifier.doi | 10.1007/s10068-016-0050-6 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.25, no.1, pp.355 - 360 | - |
dc.identifier.kciid | ART002082064 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84958250603 | - |
dc.citation.endPage | 360 | - |
dc.citation.startPage | 355 | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Hwang, Ji-Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Jung-Eun | - |
dc.contributor.affiliatedAuthor | Song, Yoon-Jae | - |
dc.contributor.affiliatedAuthor | Park, Jong-Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | E. coli bacteriophage | - |
dc.subject.keywordAuthor | pro-inflammatory cytokine | - |
dc.subject.keywordAuthor | phage-fed rat | - |
dc.subject.keywordPlus | PHAGE THERAPY | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.