Preparation of particle-attached microneedles using a dry coating process
DC Field | Value | Language |
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dc.contributor.author | Choi, Jeong-Eun | - |
dc.contributor.author | Cha, Hye-Ran | - |
dc.contributor.author | Kim, Suwan | - |
dc.contributor.author | Kim, Ji Seok | - |
dc.contributor.author | Kim, Mun-Jin | - |
dc.contributor.author | Chung, Hyeon Woo | - |
dc.contributor.author | Baek, Seung-Ki | - |
dc.contributor.author | Lee, Jae Myun | - |
dc.contributor.author | Park, Jung-Hwan | - |
dc.date.accessioned | 2023-01-04T04:40:20Z | - |
dc.date.available | 2023-01-04T04:40:20Z | - |
dc.date.created | 2023-01-04 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86422 | - |
dc.description.abstract | The standard process for manufacturing microneedles containing API requires a way to process the API, including dissolving the API in a co-solvent and a drying process. In this study, the authors introduce a novel microneedle system that involves physically attaching API particles to the biocompatible adhesive surface of the microneedles. To manufacture particle-attached microneedles, an adhesive surface was prepared by coating polydimethylsiloxane (PDMS) mixed with an elastomer base and a curing agent at a ratio of 40:1 (PDMS40) onto polylactic acid microneedles (PLA), and then attaching ovalbumin (OVA) particles with a mean diameter of 10 mu m to the PDMS adhesive layer. The OVA particles were delivered for 5 min into porcine skin with a delivery efficiency of 93% ex vivo and into mouse skin with a delivery efficiency of over 90% in vivo. Finally, mouse experiments with OVA particle-attached microneedles showed a value of OVA antibody titer similar to that produced by intramuscular administration. Particle-attached microneedles are a novel microneedle system with a dry coating process and rapid API delivery into the skin. Particle-attached microneedles can provide a wide range of applications for administering drugs and vaccines. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.title | Preparation of particle-attached microneedles using a dry coating process | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000888057900004 | - |
dc.identifier.doi | 10.1016/j.jconrel.2022.10.003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.351, pp.1003 - 1016 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85139590662 | - |
dc.citation.endPage | 1016 | - |
dc.citation.startPage | 1003 | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 351 | - |
dc.contributor.affiliatedAuthor | Choi, Jeong-Eun | - |
dc.contributor.affiliatedAuthor | Kim, Suwan | - |
dc.contributor.affiliatedAuthor | Kim, Mun-Jin | - |
dc.contributor.affiliatedAuthor | Park, Jung-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Particle-attached microneedles | - |
dc.subject.keywordAuthor | Physical attachment | - |
dc.subject.keywordAuthor | Polydimethylsiloxane | - |
dc.subject.keywordAuthor | Dry coating | - |
dc.subject.keywordAuthor | Rapid delivery | - |
dc.subject.keywordPlus | LOADED DISSOLVING MICRONEEDLES | - |
dc.subject.keywordPlus | INFLUENZA VACCINE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | INSERTION | - |
dc.subject.keywordPlus | FORCE | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | DETACHMENT | - |
dc.subject.keywordPlus | STABILITY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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