Validation of the revised diagnostic criteria for primary plasma cell leukemia by the Korean Multiple Myeloma Working Partyopen access
- Authors
- Jung, Sung-Hoon; Kim, Kihyun; Yoon, Sang Eun; Moon, Joon Ho; Kim, Dajung; Kim, Hyo Jung; Kim, Min Kyoung; Ha Kim, Kyoung; Lee, Hyun Jung; Lee, Ji Hyun; Kim, Sung-Hyun; Yoo, Kawi Han; Lee, Jae Hoon; Lee, Je-Jung
- Issue Date
- Nov-2022
- Publisher
- SPRINGERNATURE
- Citation
- BLOOD CANCER JOURNAL, v.12, no.11
- Journal Title
- BLOOD CANCER JOURNAL
- Volume
- 12
- Number
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86424
- DOI
- 10.1038/s41408-022-00755-w
- ISSN
- 2044-5385
- Abstract
- The International Myeloma Working Group has recently revised the diagnostic criteria for primary plasma cell leukemia (PCL) to circulating plasma cells (CPCs) >= 5% in a peripheral blood smear. The present study validated new criteria in patients with multiple myeloma or PCL diagnosed using the previous diagnostic criteria, who were administered immunomodulatory drugs or proteasome inhibitors as induction therapy. We analyzed the medical records of 1357 patients from eight hospitals in South Korea. The median age of the all patients was 64 years, and 187 (13.8%) had CPCs at diagnosis. Only 79 (5.8%) of the patients had >= 5% CPCs. The median overall survival (OS) of patients with CPCs >= 5% and >= 20% was similar, but had significantly inferior median progression-free survival (PFS) and median OS than those with CPCs < 5% (13.1 vs. 21.5 months, P < 0.001, and 21.5 vs. 60.9 months, P < 0.001, respectively). Primary PCL diagnosed using the revised criteria presented with higher total calcium levels and serum creatinine levels, lower platelet counts and frequent organomegaly and plasmacytoma at diagnosis. Univariate and multivariate analyses demonstrated that the presence of plasmacytoma and elevated serum beta 2-microglobulin were significantly associated with OS in primary PCL. In conclusion, the revised criterion of CPCs >= 5% in a peripheral blood smear is appropriate for PCL diagnosis.
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