Evaluation of Genotoxicity of SU-Eohyeol Pharmacopuncture Using an In Vitro Chromosome Aberration Test in Chinese Hamster Lung Cell
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ku, Jaseung | - |
dc.contributor.author | Hwang, Ji Hye | - |
dc.date.accessioned | 2023-01-04T15:40:10Z | - |
dc.date.available | 2023-01-04T15:40:10Z | - |
dc.date.created | 2022-09-24 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 2093-6966 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86437 | - |
dc.description.abstract | Objectives: This study was conducted to evaluate the safety of SU-Eohyeol pharmacopuncture (SUEP) by assessing its potential to cause chromosomal abnormalities in Chinese hamster lung cells (CHL/IC). Methods: A dose-curve was conducted to determine the highest dose of SUEP. Doses of 10, 5, 2.5, 1.25, 0.625, and 0.313% were used, and no cytotoxicity or SUEP precipitation was observed. SUEP doses of 10, 5, and 2.5%, with positive and negative controls, were used in a chromosome aberration test. Results: In this study, the frequency of abnormal chromosomal cells in the SUEP group did not show a statistically significant difference from that of the negative control group in short-term treatments with and without metabolic activation and the continuous treatment without metabolic activation. Compared with the negative control group, the positive control group had a significantly higher frequency of cells with structural chromosomal abnormalities. This test’s results satisfied all conditions for determining the results. Conclusion: SUEP did not induce chromosomal aberrations under the conditions of this study. Other toxicity evaluations, safety studies in humans, and various clinical trials are required to evaluate the safety and efficacy of SUEP. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한약침학회 | - |
dc.relation.isPartOf | Journal of Pharmacopuncture | - |
dc.title | Evaluation of Genotoxicity of SU-Eohyeol Pharmacopuncture Using an In Vitro Chromosome Aberration Test in Chinese Hamster Lung Cell | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000869994300005 | - |
dc.identifier.doi | 10.3831/KPI.2022.25.3.290 | - |
dc.identifier.bibliographicCitation | Journal of Pharmacopuncture, v.25, no.3, pp.290 - 300 | - |
dc.identifier.kciid | ART002877670 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85144662583 | - |
dc.citation.endPage | 300 | - |
dc.citation.startPage | 290 | - |
dc.citation.title | Journal of Pharmacopuncture | - |
dc.citation.volume | 25 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Hwang, Ji Hye | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Keywords: safety | - |
dc.subject.keywordAuthor | in vitro chromosome aberration test | - |
dc.subject.keywordAuthor | jungsongouhyul pharmacopuncture | - |
dc.subject.keywordAuthor | cervi parvum cornu | - |
dc.subject.keywordAuthor | su-eohyeol | - |
dc.subject.keywordAuthor | korean medicine | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.