Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities
DC Field | Value | Language |
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dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T03:41:17Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8644 | - |
dc.description.abstract | Eleven new abietane-type diterpenes, holophyllins D-N (1-11), and 17 known analogues (12-28), were isolated from a MeOH extract of the trunk of Abies holophylla. The chemical structures of 1-11 were determined through spectroscopic data analysis, including NMR (H-1 and C-13 NMR, DEPT, H-1-H-1 COSY, HMQC, HMBC, and NOESY) and HRFABMS methods. All isolated compounds (1-28) were evaluated for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116), for their potential neuroprotective effects through induction of nerve growth factor in C6 glioma cells, and for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia BV2 cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.subject | ABIETANE DITERPENOIDS | - |
dc.subject | LARIX-KAEMPFERI | - |
dc.subject | ACID | - |
dc.subject | CONSTITUENTS | - |
dc.subject | BIOACTIVITIES | - |
dc.subject | MUSHROOM | - |
dc.subject | CONES | - |
dc.title | Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000371282000016 | - |
dc.identifier.doi | 10.1021/acs.jnatprod.5b01053 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.79, no.2, pp.387 - 394 | - |
dc.identifier.scopusid | 2-s2.0-84959450456 | - |
dc.citation.endPage | 394 | - |
dc.citation.startPage | 387 | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 79 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ABIETANE DITERPENOIDS | - |
dc.subject.keywordPlus | LARIX-KAEMPFERI | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | BIOACTIVITIES | - |
dc.subject.keywordPlus | MUSHROOM | - |
dc.subject.keywordPlus | CONES | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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