Potentilloside A, a New Flavonol-bis-Glucuronide from the Leaves of Potentilla chinensis, Inhibits TNF-alpha-Induced ROS Generation and MMP-1 Secretion
- Authors
- Lee, So Young; Choi, Yea Jung; Son, So-Ri; Yoon, Young-Seo; Lee, Sun-Hee; Lee, Kyung-Tae; Lee, Sullim; Jang, Dae Sik
- Issue Date
- Dec-2022
- Publisher
- MDPI
- Keywords
- Potentila chinensis; Rosaceae; flavonol-bis-glucuronide; potentilloside A; reactive oxygen species; matrix metalloproteinase-1
- Citation
- PLANTS-BASEL, v.11, no.23
- Journal Title
- PLANTS-BASEL
- Volume
- 11
- Number
- 23
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86514
- DOI
- 10.3390/plants11233318
- ISSN
- 2223-7747
- Abstract
- The major contributor to skin aging is UV radiation, which activates pro-inflammatory cytokines including TNF-alpha. TNF-alpha is involved in the acceleration of skin aging via ROS generation and MMP-1 secretion. In our preliminary study, a 30% EtOH extract from the leaves of Potentilla chinensis (LPCE) significantly inhibited TNF-alpha-induced ROS generation in human dermal fibroblasts (HDFs). Therefore, the objective of this study is to identify the active components in LPCE. A new flavonol-bis-glucuronide (potentilloside A, 1) and 14 known compounds (2-15) were isolated from an LPCE by repeated chromatography. The chemical structure of the new compound 1 was determined by analyzing its spectroscopic data (NMR and HRMS) and by acidic hydrolysis. Nine flavonols (2-9 and 11) and two flavone glycosides (12 and 13) from P. chinensis were reported for the first time in this study. Next, we evaluated the effects of the isolates (1-15) on TNF-alpha-induced ROS generation in HDFs. As a result, all compounds significantly inhibited ROS generation. Furthermore, LPCE and potentilloside A (1) remarkably suppressed MMP-1 secretion in HDFs stimulated by TNF-alpha. The data suggested that LPCE and potentilloside A (1) are worthy of further experiments for their potential as anti-skin aging agents.
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