Antiskin Aging Effects of Indole Alkaloid N-Glycoside from Ginkgo Fruit (Ginkgo biloba fruit) on TNF-alpha-Exposed Human Dermal Fibroblasts
DC Field | Value | Language |
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dc.contributor.author | Choi, Yea Jung | - |
dc.contributor.author | Alishir, Akida | - |
dc.contributor.author | Jang, Taesu | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Lee, Sullim | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.accessioned | 2023-01-15T00:40:12Z | - |
dc.date.available | 2023-01-15T00:40:12Z | - |
dc.date.created | 2022-11-10 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86537 | - |
dc.description.abstract | Human skin aging has internal and external factors, both of which are characterized by TNF-alpha overproduction. Therefore, we aimed to identify a natural product that suppresses the damage that occurs in cutaneous dermal fibroblasts exposed to TNF-alpha. The protective effects of the indole alkaloid N-glycoside, ginkgoside B dimethyl ester (GBDE), isolated from ginkgo fruit (Ginkgo biloba fruit) were evaluated in TNF-alpha stimulated human dermal fibroblasts (HDFs). GBDE inhibited TNF-alpha-induced MMP-1 expression to 2.2 +/- 0.1-fold (p < 0.01) and reversed the decrease in collagen levels to 0.4 +/- 0.00-fold (p < 0.01) at 50 mu M. The effect of GBDE was due to the suppression of the phospolylaton of MAPKs (ERK, 0.47 +/- 0.05; JNK, 1.21 +/- 0.07; p38, 0.77 +/- 0.07-folds, p < 0.001) and Akt (0.14 +/- 0.03-fold, p < 0.001) compared to the TNF-alpha group. GBDE also reduced the expression of COX-2 to 2.06 +/- 0.12-fold (p < 0.001) and increased the expression of HO-1 to 10.64 +/- 0.2-fold (p < 0.001). In addition, GBDE inhibited the expression of the pro-inflammatory cytokines (IL-8, 2.2 +/- 0.0; IL-1 beta, 1.6 +/- 0.0; IL-6, 2.0 +/- 0.10-folds, p < 0.05). These results provide experimental evidence that GBDE can protect against skin damage, including aging. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.title | Antiskin Aging Effects of Indole Alkaloid N-Glycoside from Ginkgo Fruit (Ginkgo biloba fruit) on TNF-alpha-Exposed Human Dermal Fibroblasts | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000875628900001 | - |
dc.identifier.doi | 10.1021/acs.jafc.2c05769 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.70, no.42, pp.13651 - 13660 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85140314338 | - |
dc.citation.endPage | 13660 | - |
dc.citation.startPage | 13651 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 70 | - |
dc.citation.number | 42 | - |
dc.contributor.affiliatedAuthor | Choi, Yea Jung | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.contributor.affiliatedAuthor | Lee, Sullim | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | ginkgo fruitsi | - |
dc.subject.keywordAuthor | indole alkaloid N-glycoside | - |
dc.subject.keywordAuthor | antiskin aging | - |
dc.subject.keywordAuthor | TNF-? | - |
dc.subject.keywordAuthor | human dermal fibroblasts | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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