Klotho and S100A8/A9 as Discriminative Markers between Pre-Renal and Intrinsic Acute Kidney Injury
DC Field | Value | Language |
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dc.contributor.author | Kim, Ae Jin | - |
dc.contributor.author | Ro, Han | - |
dc.contributor.author | Kim, Hyunsook | - |
dc.contributor.author | Chang, Jae Hyun | - |
dc.contributor.author | Lee, Hyun Hee | - |
dc.contributor.author | Chung, Wookyung | - |
dc.contributor.author | Jung, Ji Yong | - |
dc.date.available | 2020-02-28T03:41:33Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-01-22 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8663 | - |
dc.description.abstract | Early detection and accurate differentiation of the cause of AKI may improve the prognosis of the patient. However, to date, there are few reliable biomarkers that can discriminate between pre-renal and intrinsic AKI. In this study, we determined whether AKI is associated with altered serum and urinary levels of Klotho, S100A8/A9 (an endogenous ligand of toll-like receptor 4), and neutrophil gelatinase-associated lipocalin (NGAL), which may allow differentiation between pre-renal and intrinsic AKI. A volume-depleted pre-renal AKI model was induced in male Sprague Dawley rats fed a low-salt diet (0.03%) without water 96 h before two intraperitoneal (IP) injections of furosemide (20 mg/kg) at a 24 h interval. In contrast, in the cisplatin-induced intrinsic AKI model, animals were given a single IP injection of cisplatin (5 mg/kg). All of the animals were euthanized 72 h after the first IP injection. Serum and urinary levels of Klotho, S100A8/A9, and NGAL were measured using an enzyme-linked immunosorbent assay. We also performed a proof-of-concept cross-sectional study to measure serum and urinary biomarkers in 61 hospitalized patients with established AKI. Compared to the intrinsic AKI group, the pre-renal AKI group showed a marked depression in urinary Klotho levels (13.21 +/- 17.32 vs. 72.97 +/- 17.96 pg/mL; P = 0.002). In addition, the intrinsic AKI group showed marked elevation of S100A8/A9 levels compared to the pre-renal AKI group (2629.97 +/- 598.05 ng/mL vs. 685.09 +/- 111.65 ng/mL; P = 0.002 in serum; 3361.11 +/- 250.86 ng/mL vs. 741.72 +/- 101.96 ng/mL; P = 0.003 in urine). There was no difference in serum and urinary NGAL levels between the pre-renal and intrinsic AKI groups. The proof-of-concept study with the hospitalized AKI patients also demonstrated decreased urinary Klotho in pre-renal AKI patients and increased urinary S100A8/A9 concentrations in intrinsic AKI patients. The attenuation of urinary Klotho and increase in urinary S100A8/A9 may allow differentiation between pre-renal and intrinsic AKI. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.subject | GELATINASE-ASSOCIATED LIPOCALIN | - |
dc.subject | MYELOID-RELATED PROTEIN-14 | - |
dc.subject | URINARY BIOMARKER | - |
dc.subject | TISSUE EXPRESSION | - |
dc.subject | CALPROTECTIN | - |
dc.subject | CREATININE | - |
dc.subject | NGAL | - |
dc.subject | GENE | - |
dc.subject | MYELOID-RELATED-PROTEIN-8/14 | - |
dc.subject | MORTALITY | - |
dc.title | Klotho and S100A8/A9 as Discriminative Markers between Pre-Renal and Intrinsic Acute Kidney Injury | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000368655300081 | - |
dc.identifier.doi | 10.1371/journal.pone.0147255 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.11, no.1 | - |
dc.identifier.scopusid | 2-s2.0-84958231008 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kim, Ae Jin | - |
dc.contributor.affiliatedAuthor | Ro, Han | - |
dc.contributor.affiliatedAuthor | Kim, Hyunsook | - |
dc.contributor.affiliatedAuthor | Chang, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Hee | - |
dc.contributor.affiliatedAuthor | Chung, Wookyung | - |
dc.contributor.affiliatedAuthor | Jung, Ji Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GELATINASE-ASSOCIATED LIPOCALIN | - |
dc.subject.keywordPlus | MYELOID-RELATED PROTEIN-14 | - |
dc.subject.keywordPlus | URINARY BIOMARKER | - |
dc.subject.keywordPlus | TISSUE EXPRESSION | - |
dc.subject.keywordPlus | CALPROTECTIN | - |
dc.subject.keywordPlus | CREATININE | - |
dc.subject.keywordPlus | NGAL | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | MYELOID-RELATED-PROTEIN-8/14 | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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