Protective role of engineered extracellular vesicles loaded quercetin nanoparticles as anti-viral therapy against SARS-CoV-2 infection: A prospective review
DC Field | Value | Language |
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dc.contributor.author | Raghav, Alok | - |
dc.contributor.author | Giri, Richa | - |
dc.contributor.author | Agarwal, Saurabh | - |
dc.contributor.author | Kala, Sanjay | - |
dc.contributor.author | Jeong, Goo-Bo- | - |
dc.date.accessioned | 2023-01-19T00:40:24Z | - |
dc.date.available | 2023-01-19T00:40:24Z | - |
dc.date.created | 2023-01-18 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86647 | - |
dc.description.abstract | Quercetin (QCT) is a naturally occurring phenolic flavonoid compound with inbuilt characteristics of antioxidant, anti-inflammatory, and immune protection. Several recent studies have shown that QCT and QCTits nanoparticles have therapeutic potential against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Novel therapeutics also include the implication of extracellular vesicles (EVs) to protect from SARS-CoV-2 viral infection. This article highlighted the therapeutic/prophylactic potential of engineered EVs loaded with QCT against SARS-CoV-2 infection. Several biotechnological engineering approaches are available to deliver EVs loaded with QCT nanoparticles. Among these biotechnological advances, a specific approach with significantly higher efficiency and yield has to be opted to fabricate such drug delivery of nano molecules, especially to combat SARS-CoV-2 infection. The current treatment regime protects the human body from virus infection but has some limitations including drugs and long-term steroid side effects. However, the vaccine strategy is somehow effective in inhibiting the spread of coronavirus disease-19 (COVID-19) infection. Moreover, the proposed exosomal therapy met the current need to repair the damaged tissue along with inhibition of COVID-19-associated complications at the tissue level. These scientific findings expand the possibilities and predictability of developing a novel and cost-effective therapeutic approach that combines the dual molecule, EVs and QCT nanoparticles, to treat SARS-CoV-2 infection. Therefore, the most suitable engineering method to fabricate such a drug delivery system should be better understood before developing novel therapeutics for clinical purposes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN IMMUNOLOGY | - |
dc.title | Protective role of engineered extracellular vesicles loaded quercetin nanoparticles as anti-viral therapy against SARS-CoV-2 infection: A prospective review | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000902012400001 | - |
dc.identifier.doi | 10.3389/fimmu.2022.1040027 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN IMMUNOLOGY, v.13 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85144549669 | - |
dc.citation.title | FRONTIERS IN IMMUNOLOGY | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Raghav, Alok | - |
dc.contributor.affiliatedAuthor | Jeong, Goo-Bo- | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Quercetin | - |
dc.subject.keywordAuthor | extracellular vesicle | - |
dc.subject.keywordAuthor | SARS CoV2 | - |
dc.subject.keywordAuthor | nanoparticle | - |
dc.subject.keywordAuthor | therapeutic target | - |
dc.subject.keywordPlus | MESENCHYMAL STROMAL CELLS | - |
dc.subject.keywordPlus | DRUG-DELIVERY VEHICLES | - |
dc.subject.keywordPlus | SURFACE FUNCTIONALIZATION | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY ACTIVITY | - |
dc.subject.keywordPlus | FLAVONOL QUERCETIN | - |
dc.subject.keywordPlus | EARLY-STAGE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | EXOSOMES | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | COVID-19 | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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