Alterations of presynaptic proteins in autism spectrum disorder
DC Field | Value | Language |
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dc.contributor.author | Yeo, Xin Yi | - |
dc.contributor.author | Lim, Yi Tang | - |
dc.contributor.author | Chae, Woo Ri | - |
dc.contributor.author | Park, Chungwon | - |
dc.contributor.author | Park, Hyokeun | - |
dc.contributor.author | Jung, Sangyong | - |
dc.date.accessioned | 2023-01-19T00:40:30Z | - |
dc.date.available | 2023-01-19T00:40:30Z | - |
dc.date.created | 2023-01-18 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 1662-5099 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86655 | - |
dc.description.abstract | The expanded use of hypothesis-free gene analysis methods in autism research has significantly increased the number of genetic risk factors associated with the pathogenesis of autism. A further examination of the implicated genes directly revealed the involvement in processes pertinent to neuronal differentiation, development, and function, with a predominant contribution from the regulators of synaptic function. Despite the importance of presynaptic function in synaptic transmission, the regulation of neuronal network activity, and the final behavioral output, there is a relative lack of understanding of the presynaptic contribution to the pathology of autism. Here, we will review the close association among autism-related mutations, autism spectrum disorders (ASD) phenotypes, and the altered presynaptic protein functions through a systematic examination of the presynaptic risk genes relating to the critical stages of synaptogenesis and neurotransmission. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.title | Alterations of presynaptic proteins in autism spectrum disorder | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000892823800001 | - |
dc.identifier.doi | 10.3389/fnmol.2022.1062878 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN MOLECULAR NEUROSCIENCE, v.15 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85143318666 | - |
dc.citation.title | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.citation.volume | 15 | - |
dc.contributor.affiliatedAuthor | Chae, Woo Ri | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | presynaptic proteins | - |
dc.subject.keywordAuthor | synaptopathy | - |
dc.subject.keywordAuthor | presynaptic vesicle dynamics | - |
dc.subject.keywordAuthor | vesicle release machinery | - |
dc.subject.keywordAuthor | synaptogenesis | - |
dc.subject.keywordAuthor | autism spectrum disorders (ASD) | - |
dc.subject.keywordPlus | SYNAPTIC VESICLE PROTEIN | - |
dc.subject.keywordPlus | CELL-ADHESION MOLECULES | - |
dc.subject.keywordPlus | OF-FUNCTION MUTATIONS | - |
dc.subject.keywordPlus | SYNAPSIN-I | - |
dc.subject.keywordPlus | DE-NOVO | - |
dc.subject.keywordPlus | ACTIVE ZONE | - |
dc.subject.keywordPlus | MENTAL-RETARDATION | - |
dc.subject.keywordPlus | DOWN-SYNDROME | - |
dc.subject.keywordPlus | NEURONAL-ACTIVITY | - |
dc.subject.keywordPlus | DROSOPHILA DSCAM | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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