Dual (pH- and ROS-) Responsive Antibacterial MXene-Based Nanocarrier for Drug Delivery
DC Field | Value | Language |
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dc.contributor.author | Zhang, Wei-Jin | - |
dc.contributor.author | Li, Shuwei | - |
dc.contributor.author | Yan, Yong-Zhu | - |
dc.contributor.author | Park, Sung Soo | - |
dc.contributor.author | Mohan, Anandhu | - |
dc.contributor.author | Chung, Ildoo | - |
dc.contributor.author | Ahn, Suk-kyun | - |
dc.contributor.author | Kim, Jung Rae | - |
dc.contributor.author | Ha, Chang-Sik | - |
dc.date.accessioned | 2023-01-19T01:41:46Z | - |
dc.date.available | 2023-01-19T01:41:46Z | - |
dc.date.created | 2023-01-18 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86685 | - |
dc.description.abstract | In this study, a novel MXene (Ti3C2Tx)-based nanocarrier was developed for drug delivery. MXene nanosheets were functionalized with 3, 3 '-diselanediyldipropionic acid (DSeDPA), followed by grafting doxorubicin (DOX) as a model drug to the surface of functionalized MXene nanosheets (MXene-Se-DOX). The nanosheets were characterized using scanning electron microscopy, atomic force microscopy (AFM), transmission electron microscopy, energy-dispersive X-ray spectroscopy (EDX), nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and zeta potential techniques. The drug-loading capacity (17.95%) and encapsulation efficiency (41.66%) were determined using ultraviolet-visible spectroscopy. The lateral size and thickness of the MXene nanosheets measured using AFM were 200 nm and 1.5 nm, respectively. The drug release behavior of the MXene-Se-DOX nanosheets was evaluated under different medium conditions, and the nanosheets demonstrated outstanding dual (reactive oxygen species (ROS)- and pH-) responsive properties. Furthermore, the MXene-Se-DOX nanosheets exhibited excellent antibacterial activity against both Gram-negative E. coli and Gram-positive B. subtilis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.title | Dual (pH- and ROS-) Responsive Antibacterial MXene-Based Nanocarrier for Drug Delivery | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000897349000001 | - |
dc.identifier.doi | 10.3390/ijms232314925 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.23 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85143699884 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 23 | - |
dc.citation.number | 23 | - |
dc.contributor.affiliatedAuthor | Mohan, Anandhu | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | MXene | - |
dc.subject.keywordAuthor | ROS-responsive | - |
dc.subject.keywordAuthor | pH-responsive | - |
dc.subject.keywordAuthor | antibacterial activity | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | NANOSHEETS | - |
dc.subject.keywordPlus | SMART | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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