Immunostimulatory Activity of Cordyceps militaris Fermented with Pediococcus pentosaceus SC11 Isolated from a Salted Small Octopus in Cyclophosphamide-Induced Immunocompromised Mice and Its Inhibitory Activity against SARS-CoV 3CL Protease
DC Field | Value | Language |
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dc.contributor.author | Dhong, Kyu-Ree | - |
dc.contributor.author | Kwon, Ha-Kyoung | - |
dc.contributor.author | Park, Hye-Jin | - |
dc.date.accessioned | 2023-01-19T01:42:11Z | - |
dc.date.available | 2023-01-19T01:42:11Z | - |
dc.date.created | 2023-01-18 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 2076-2607 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86714 | - |
dc.description.abstract | In this study, we investigated the immune-enhancing and anti-viral effects of germinated Rhynchosia nulubilis (GRC) fermented with Pediococcus pentosaceus SC11 (GRC-SC11) isolated from a salted small octopus. The cordycepin, beta-glucan, and total flavonoid contents increased in GRC after SC11 fermentation. GRC-SC11 inhibits 3CL protease activity in severe acute respiratory syndrome-associated coronavirus (SARS-CoV). GRC-SC11 significantly increased thymus and spleen indices in immunocompromised mice. The rate of splenocyte proliferation was higher in GRC-SC11-treated immunocompromised mice than that in GRC-treated immunocompromised mice in the presence or absence of concanavalin A. In addition, GRC-SC11 increased the phagocytic activity and nitric oxide production in immunocompromised mice. The mRNA expression of interferon-gamma (IFN-gamma), interferon-alpha (IFN-alpha), and interferon-stimulated gene 15 (ISG15) was up-regulated in GRC-SC11 treated RAW 264.7 macrophages, compared to GRC. Our study indicates that GRC-SC11 might be a potential therapeutic agent for immunocompromised patients who are vulnerable to SARS-CoV infection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MICROORGANISMS | - |
dc.title | Immunostimulatory Activity of Cordyceps militaris Fermented with Pediococcus pentosaceus SC11 Isolated from a Salted Small Octopus in Cyclophosphamide-Induced Immunocompromised Mice and Its Inhibitory Activity against SARS-CoV 3CL Protease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000904499600001 | - |
dc.identifier.doi | 10.3390/microorganisms10122321 | - |
dc.identifier.bibliographicCitation | MICROORGANISMS, v.10, no.12 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85144649238 | - |
dc.citation.title | MICROORGANISMS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Dhong, Kyu-Ree | - |
dc.contributor.affiliatedAuthor | Kwon, Ha-Kyoung | - |
dc.contributor.affiliatedAuthor | Park, Hye-Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cordyceps militaris grown on germinated Rhychosia nulubilis fermented with Pediococcus pentosaceus SC11 (GRC-SC11) | - |
dc.subject.keywordAuthor | immune stimulatory | - |
dc.subject.keywordAuthor | cyclophosphamide | - |
dc.subject.keywordAuthor | SARS-CoV 3CL protease | - |
dc.subject.keywordAuthor | splenocyte proliferation | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | phagocytic activity | - |
dc.subject.keywordPlus | LACTIC-ACID BACTERIA | - |
dc.subject.keywordPlus | INDUCED IMMUNOSUPPRESSION | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | GERMINATED SOYBEANS | - |
dc.subject.keywordPlus | PHELLINUS-LINTEUS | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | IMMUNOMODULATORY ACTIVITIES | - |
dc.subject.keywordPlus | RIBONUCLEOTIDE REDUCTASE | - |
dc.subject.keywordPlus | POLYSACCHARIDES ENHANCE | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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