Black Phosphorus (BP) Nanodots for Potential Biomedical Applications
- Authors
- Lee, Hyun Uk; Park, So Young; Lee, Soon Chang; Choi, Saehae; Seo, Soonjoo; Kim, Hyeran; Won, Jonghan; Choi, Kyuseok; Kang, Kyoung Suk; Park, Hyun Gyu; Kim, Hee-Sik; An, Ha Rim; Jeong, Kwang-Hun; Lee, Young-Chul; Lee, Jouhahn
- Issue Date
- 13-Jan-2016
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- black phosphorus; cell imaging; cytotoxicity; medical applications; nanodots
- Citation
- SMALL, v.12, no.2, pp.214 - 219
- Journal Title
- SMALL
- Volume
- 12
- Number
- 2
- Start Page
- 214
- End Page
- 219
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8675
- DOI
- 10.1002/smll.201502756
- ISSN
- 1613-6810
- Abstract
- Recently, the appeal of 2D black phosphorus (BP) has been rising due to its unique optical and electronic properties with a tunable band gap (approximate to 0.3-1.5 eV). While numerous research efforts have recently been devoted to nano-and optoelectronic applications of BP, no attention has been paid to promising medical applications. In this article, the preparation of BP-nanodots of a few nm to <20 nm with an average diameter of approximate to 10 nm and height of approximate to 8.7 nm is reported by a modified ultrasonication-assisted solution method. Stable formation of nontoxic phosphates and phosphonates from BP crystals with exposure in water or air is observed. As for the BP-nanodot crystals' stability (ionization and persistence of fluorescent intensity) in aqueous solution, after 10 d, approximate to 80% at 1.5 mg mL(-1) are degraded (i.e., ionized) in phosphate buffered saline. They showed no or little cytotoxic cell-viability effects in vitro involving blue-and green-fluorescence cell imaging. Thus, BP-nanodots can be considered a promising agent for drug delivery or cellular tracking systems.
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