Antiviral Activities of Ethyl Pheophorbides a and b Isolated from Aster pseudoglehnii against Influenza Virusesopen access
- Authors
- Park, Subin; Kim, Ji-Young; Kwon, Hak Cheol; Jang, Dae Sik; Song, Yoon-Jae
- Issue Date
- Jan-2023
- Publisher
- MDPI
- Keywords
- Aster pseudoglehnii; endemic plants; ethyl pheophorbide; chlorophyll derivative; virucidal
- Citation
- MOLECULES, v.28, no.1
- Journal Title
- MOLECULES
- Volume
- 28
- Number
- 1
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86770
- DOI
- 10.3390/molecules28010041
- ISSN
- 1420-3049
- Abstract
- Screening of the antiviral and virucidal activities of ethanol extracts from plants endemic to the Republic of Korea revealed the inhibitory activity of a 70% ethanol extract of the whole plant of A. pseudoglehnii (APE) against influenza virus infection. Two chlorophyll derivatives, ethyl pheophorbides a and b, isolated as active components of APE, exerted virucidal effects with no evident cytotoxicity. These compounds were effective only under conditions of direct incubation with the virus, and exerted no effects on the influenza A virus (IAV) surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). Interestingly, virucidal activities of ethyl pheophorbides a and b were observed against enveloped but not non-enveloped viruses, suggesting that these compounds act by affecting the integrity of the viral membrane and reducing infectivity.
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Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
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