Non-equivalent interactions between amino-terminal domains of neighboring lambda integrase protomers direct holliday junction resolution
DC Field | Value | Language |
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dc.contributor.author | Lee SY | - |
dc.contributor.author | Radman-Livaja M | - |
dc.contributor.author | Warren D | - |
dc.contributor.author | Aihara H | - |
dc.contributor.author | Ellenberger T | - |
dc.contributor.author | Landy A | - |
dc.date.accessioned | 2023-02-07T14:40:06Z | - |
dc.date.available | 2023-02-07T14:40:06Z | - |
dc.date.created | 2023-02-05 | - |
dc.date.issued | 2005-01 | - |
dc.identifier.issn | 0022-2836 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86837 | - |
dc.description.abstract | The bacteriophage lambda site-specific recombinase (Int), in contrast to other family members such as Cre and Flp, has an amino-terminal domain that binds "arm-type" DNA sequences different and distant from those involved in strand exchange. This defining feature of the heterobivalent recombinases confers a directionality and regulation that is unique among all recombination pathways. We show that the amino-terminal domain is not a simple "accessory" element, as originally thought, but rather is incorporated into the core of the recombination mechanism, where it is well positioned to exert its profound effects. The results reveal an unexpected pattern of intermolecular interactions between the amino-terminal domain of one protomer and the linker region of its neighbor within the tetrameric Int complex and provide insights into those features distinguishing an "active" from an "inactive" pair of Ints during Holliday junction resolution. (C) 2004 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.title | Non-equivalent interactions between amino-terminal domains of neighboring lambda integrase protomers direct holliday junction resolution | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000225786700006 | - |
dc.identifier.doi | 10.1016/j.jmb.2004.10.068 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR BIOLOGY, v.345, no.3, pp.475 - 485 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-9644268885 | - |
dc.citation.endPage | 485 | - |
dc.citation.startPage | 475 | - |
dc.citation.title | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.citation.volume | 345 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee SY | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | site-specific recombination | - |
dc.subject.keywordAuthor | protein-protein interactions | - |
dc.subject.keywordAuthor | multimeric complexes | - |
dc.subject.keywordAuthor | protein-DNA interactions | - |
dc.subject.keywordAuthor | E. coli bacteriophage | - |
dc.subject.keywordPlus | SITE-SPECIFIC RECOMBINATION | - |
dc.subject.keywordPlus | 4-WAY DNA JUNCTION | - |
dc.subject.keywordPlus | ATTACHMENT SITES | - |
dc.subject.keywordPlus | C-TERMINUS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | INT | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | DETERMINANTS | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | SPECIFICITY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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