Alzheimer's disease-like cortical atrophy mediates the effect of air pollution on global cognitive function
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Jaelim | - |
dc.contributor.author | Jang, Heeseon | - |
dc.contributor.author | Park, Hyunji | - |
dc.contributor.author | Noh, Young | - |
dc.contributor.author | Sohn, Jungwoo | - |
dc.contributor.author | Koh, Sang-Baek | - |
dc.contributor.author | Lee, Seung-Koo | - |
dc.contributor.author | Kim, Sun-Young | - |
dc.contributor.author | Kim, Changsoo | - |
dc.date.accessioned | 2023-02-23T01:40:10Z | - |
dc.date.available | 2023-02-23T01:40:10Z | - |
dc.date.created | 2023-02-14 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 0160-4120 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86923 | - |
dc.description.abstract | Little is known about the effect of air pollution on Alzheimer's disease (AD)-specific brain structural pathologies. There is also a lack of evidence on whether this effect leads to poorer cognitive function. We investigated whether, and the extent to which, AD-like cortical atrophy mediated the association between air pollution exposures and cognitive function in dementia-free adults. We used cross-sectional data from 640 participants who underwent brain magnetic resonance imaging and the Montreal Cognitive Assessment (MoCA). Mean cortical thickness (as the measure of global cortical atrophy) and machine learning-based AD-like cortical atrophy score were estimated from brain images. Concentrations of particulate matter with diameters < 10 mu m (PM10) and < 2.5 mu m (PM2.5) and nitrogen dioxide (NO2) were estimated based on each participant's residential address. Following the product method, a mediation effect was tested by conducting a series of three regression analyses (exposure to outcome; exposure to mediator; and exposure and mediator to outcome). A 10 mu g/m3 increase in PM10 (13 =-1.13; 95 % CI,-1.73 to-0.53) and a 10 ppb increase in NO2 (13 =-1.09; 95 % CI,-1.40 to-0.78) were significantly associated with a lower MoCA score. PM10 (13 = 0.27; 95 % CI, 0.06 to 0.48) and NO2 (13 = 0.35; 95 % CI, 0.25 to 0.45) were significantly associated with an increased AD-like cortical atrophy score. Effects of PM10 and NO2 on MoCA scores were significantly mediated by mean cortical thickness (proportions mediated: 25 %-28 %) and AD-like cortical atrophy scores (13 %-16 %). The findings suggest that air pollution exposures may induce AD-like cortical atrophy, and that this effect may lead to poorer cognitive function in dementia-free adults. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | ENVIRONMENT INTERNATIONAL | - |
dc.title | Alzheimer's disease-like cortical atrophy mediates the effect of air pollution on global cognitive function | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000909741900001 | - |
dc.identifier.doi | 10.1016/j.envint.2022.107703 | - |
dc.identifier.bibliographicCitation | ENVIRONMENT INTERNATIONAL, v.171 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85147038837 | - |
dc.citation.title | ENVIRONMENT INTERNATIONAL | - |
dc.citation.volume | 171 | - |
dc.contributor.affiliatedAuthor | Noh, Young | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Epidemiology | - |
dc.subject.keywordAuthor | Air pollution | - |
dc.subject.keywordAuthor | Alzheimer?s disease | - |
dc.subject.keywordAuthor | Cortical atrophy | - |
dc.subject.keywordAuthor | Cognitive function | - |
dc.subject.keywordAuthor | Mediation analysis | - |
dc.subject.keywordPlus | HYPOTHETICAL MODEL | - |
dc.subject.keywordPlus | PARTICULATE MATTER | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.