Network Pharmacological Analysis on the Herbal Combinations for Mitigating Inflammation in Respiratory Tracts and Experimental Evaluation
DC Field | Value | Language |
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dc.contributor.author | Jang, Dongyeop | - |
dc.contributor.author | Lee, Myong Jin | - |
dc.contributor.author | Kim, Kang Sub | - |
dc.contributor.author | Kim, Chang-Eop | - |
dc.contributor.author | Jung, Jong Ho | - |
dc.contributor.author | Cho, Minkwan | - |
dc.contributor.author | Hong, Bo-Hee | - |
dc.contributor.author | Park, Shin Jung | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2023-02-25T01:40:07Z | - |
dc.date.available | 2023-02-25T01:40:07Z | - |
dc.date.created | 2023-02-14 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2227-9032 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86933 | - |
dc.description.abstract | The regulation of inflammatory mediators, such as TNF-alpha, IL-6, IL-1 beta, and leukotriene B4, could play a crucial role in suppressing inflammatory diseases such as COVID-19. In this study, we investigated the potential mechanisms of drug combinations comprising Ephedrae Herba, Schisandra Fructus, Platycodonis Radix, and Ginseng Radix; validated the anti-inflammatory effects of these drugs; and determined the optimal dose of the drug combinations. By constructing a herb-compound-target network, associations were identified between the herbs and tissues (such as bronchial epithelial cells and lung) and pathways (such as the TNF, NF-kappa B, and calcium signaling pathways). The drug combinations exerted anti-inflammatory effects in the RAW264.7 cell line treated with lipopolysaccharide by inhibiting the production of nitric oxide and inflammatory mediators, including TNF-alpha, IL-6, IL-1 beta, and leukotriene B4. Notably, the drug combinations inhibited PMA-induced MUC5AC mRNA expression in NCI-H292 cells. A design space analysis was carried out to determine the optimal herbal medicine combinations using the design of experiments and synergy score calculation. Consequently, a combination study of the herbal preparations confirmed their mitigating effect on inflammation in COVID-19. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | HEALTHCARE | - |
dc.title | Network Pharmacological Analysis on the Herbal Combinations for Mitigating Inflammation in Respiratory Tracts and Experimental Evaluation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000910238800001 | - |
dc.identifier.doi | 10.3390/healthcare11010143 | - |
dc.identifier.bibliographicCitation | HEALTHCARE, v.11, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85145897835 | - |
dc.citation.title | HEALTHCARE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Jang, Dongyeop | - |
dc.contributor.affiliatedAuthor | Lee, Myong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Kang Sub | - |
dc.contributor.affiliatedAuthor | Kim, Chang-Eop | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | COVID-19 complications | - |
dc.subject.keywordAuthor | herbal medicine | - |
dc.subject.keywordAuthor | synergistic effects | - |
dc.subject.keywordAuthor | network pharmacology | - |
dc.subject.keywordAuthor | design of experiments | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | MUCIN HYPERSECRETION | - |
dc.subject.keywordPlus | MUC5AC | - |
dc.subject.keywordPlus | COUGH | - |
dc.subject.keywordPlus | PLATYCODON | - |
dc.subject.keywordPlus | MEDICINE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | NEUTROPHILS | - |
dc.relation.journalResearchArea | Health Care Sciences & Services | - |
dc.relation.journalWebOfScienceCategory | Health Care Sciences & Services | - |
dc.relation.journalWebOfScienceCategory | Health Policy & Services | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
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