X-ray fluorescence studies of animal and human cell biology

Abstract

Besides biomolecules, cells contain trace elements that are important to normal cellular function. The measurement of concentrations of these chemical elements is vital. One method to accomplish this is by using X-ray fluorescence (XRF) analysis. Research on biological objects in the medical sciences can be performed efficiently with XRF techniques. Low-resolution XFM is useful in uncovering of heavy metals in tissues of experimental animal models and humans exposed to metals. A basic understanding of cell biology and organelle in cells can be achieved by using tomographic imaging of organelles. The uses of XRF for biological applications are growing into an area of extensive research. Use of XRF studies in human applications promises to open new horizons and prove XRF a highly advantageous technology. However, its use is limited and precautions must be followed while using such advanced technology. © 2022 John Wiley & Sons Ltd. All rights reserved.