RAGE Inhibitors for Targeted Therapy of Cancer: A Comprehensive Review
DC Field | Value | Language |
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dc.contributor.author | Faruqui, Tabrez | - |
dc.contributor.author | Khan, Mohd Sajid | - |
dc.contributor.author | Akhter, Yusuf | - |
dc.contributor.author | Khan, Salman | - |
dc.contributor.author | Rafi, Zeeshan | - |
dc.contributor.author | Saeed, Mohd | - |
dc.contributor.author | Han, Ihn | - |
dc.contributor.author | Choi, Eun-Ha | - |
dc.contributor.author | Yadav, Dharmendra Kumar | - |
dc.date.accessioned | 2023-03-04T01:40:10Z | - |
dc.date.available | 2023-03-04T01:40:10Z | - |
dc.date.created | 2023-02-14 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86984 | - |
dc.description.abstract | The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin family that is overexpressed in several cancers. RAGE is highly expressed in the lung, and its expression increases proportionally at the site of inflammation. This receptor can bind a variety of ligands, including advanced glycation end products, high mobility group box 1, S100 proteins, adhesion molecules, complement components, advanced lipoxidation end products, lipopolysaccharides, and other molecules that mediate cellular responses related to acute and chronic inflammation. RAGE serves as an important node for the initiation and stimulation of cell stress and growth signaling mechanisms that promote carcinogenesis, tumor propagation, and metastatic potential. In this review, we discuss different aspects of RAGE and its prominent ligands implicated in cancer pathogenesis and describe current findings that provide insights into the significant role played by RAGE in cancer. Cancer development can be hindered by inhibiting the interaction of RAGE with its ligands, and this could provide an effective strategy for cancer treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.title | RAGE Inhibitors for Targeted Therapy of Cancer: A Comprehensive Review | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000910172600001 | - |
dc.identifier.doi | 10.3390/ijms24010266 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85145898377 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Yadav, Dharmendra Kumar | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | RAGE | - |
dc.subject.keywordAuthor | RAGE inhibitor | - |
dc.subject.keywordAuthor | targeted therapy | - |
dc.subject.keywordAuthor | end products | - |
dc.subject.keywordPlus | GLYCATION END-PRODUCTS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | MOBILITY GROUP BOX-1 | - |
dc.subject.keywordPlus | CALCIUM-BINDING PROTEINS | - |
dc.subject.keywordPlus | CELL-ADHESION MOLECULES | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | HUMAN NASOPHARYNGEAL CARCINOMA | - |
dc.subject.keywordPlus | METASTASIS-ASSOCIATED PROTEIN | - |
dc.subject.keywordPlus | C-TERMINAL DOMAINS | - |
dc.subject.keywordPlus | EF-HAND PROTEIN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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