Effect and Safety of Rosuvastatin in Acute Ischemic Stroke
DC Field | Value | Language |
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dc.contributor.author | Heo, Ji Hoe | - |
dc.contributor.author | Song, Dongbeom | - |
dc.contributor.author | Nam, Hyo Suk | - |
dc.contributor.author | Kim, Eung Yeop | - |
dc.contributor.author | Kim, Young Dae | - |
dc.contributor.author | Lee, Kyung-Yul | - |
dc.contributor.author | Lee, Ki-Jeong | - |
dc.contributor.author | Yoo, Joonsang | - |
dc.contributor.author | Kim, Youn Nam | - |
dc.contributor.author | Lee, Byung Chul | - |
dc.contributor.author | Yoon, Byung-Woo | - |
dc.contributor.author | Kim, Jong S. | - |
dc.date.available | 2020-02-28T03:42:08Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 2287-6391 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8699 | - |
dc.description.abstract | Background and Purpose The benefit of statins in acute stroke remains uncertain. Statins may prevent stroke recurrence during the acute stage of stroke via pleiotropic effects. However, statins may increase the risk of intracerebral hemorrhage. We investigated the effect and safety of rosuvastatin in acute stroke patients. Methods This randomized, double-blind, multi-center trial compared rosuvastatin 20 mg and placebo in statin-naive stroke patients who underwent diffusion-weighted imaging (DWI) within 48 hours after symptom onset. The primary outcome was occurrence of new ischemic lesions on DWI at 5 or 14 days. Results This trial was stopped early after randomization of 316 patients due to slow enrollment. Among 289 patients with at least one follow-up imaging, the frequency of new ischemic lesions on DWI was not different between groups (rosuvastatin: 27/137, 19.7% vs. placebo: 36/152, 23.6%) (relative risk 0.83, 95% confidence interval 0.53-1.30). Infarct volume growth at 5 days (log-transformed volume change, rosuvastatin: 0.2 +/- 1.0 mm(3) vs. placebo: 0.3 +/- 1.3 mm(3); P=0.784) was not different, either. However, hemorrhagic infarction or parenchymal/subarachnoid hemorrhage on gradient-recalled echo magnetic resonance imaging occurred less frequently in the rosuvastatin group (6/137, 4.4%) than the placebo group (22/152, 14.5%, P=0.007). Among 314 patients with at least one dose of study medication, progression or clinical recurrence of stroke tended to occur less frequently in the rosuvastatin group (1/155, 0.6% vs. 7/159, 4.4%, P=0.067). Adverse events did not differ between groups. Conclusions The efficacy of rosuvastatin in reducing recurrence in acute stroke was inconclusive. However, statin use was safe and reduced hemorrhagic transformation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN STROKE SOC | - |
dc.relation.isPartOf | JOURNAL OF STROKE | - |
dc.subject | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject | INTRACEREBRAL HEMORRHAGE | - |
dc.subject | PILOT TRIAL | - |
dc.subject | STATINS | - |
dc.subject | CHOLESTEROL | - |
dc.subject | METAANALYSIS | - |
dc.subject | SIMVASTATIN | - |
dc.subject | EXPRESSION | - |
dc.subject | ATORVASTATIN | - |
dc.subject | RECURRENCE | - |
dc.title | Effect and Safety of Rosuvastatin in Acute Ischemic Stroke | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000371102400012 | - |
dc.identifier.doi | 10.5853/jos.2015.01578 | - |
dc.identifier.bibliographicCitation | JOURNAL OF STROKE, v.18, no.1, pp.87 - 95 | - |
dc.identifier.kciid | ART002077912 | - |
dc.identifier.scopusid | 2-s2.0-84969425019 | - |
dc.citation.endPage | 95 | - |
dc.citation.startPage | 87 | - |
dc.citation.title | JOURNAL OF STROKE | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kim, Eung Yeop | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Stroke | - |
dc.subject.keywordAuthor | Rosuvastatin | - |
dc.subject.keywordAuthor | Statin | - |
dc.subject.keywordAuthor | Diffusion-weighted imaging | - |
dc.subject.keywordPlus | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject.keywordPlus | INTRACEREBRAL HEMORRHAGE | - |
dc.subject.keywordPlus | PILOT TRIAL | - |
dc.subject.keywordPlus | STATINS | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | SIMVASTATIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ATORVASTATIN | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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