New Anti-Inflammatory beta-Resorcylic Acid Lactones Derived from an Endophytic Fungus, Colletotrichum sp.
DC Field | Value | Language |
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dc.contributor.author | Kim, Jaekyeong | - |
dc.contributor.author | Baek, Ji Yun | - |
dc.contributor.author | Bang, Sunghee | - |
dc.contributor.author | Kim, Ji-Young | - |
dc.contributor.author | Jin, Yeongwoon | - |
dc.contributor.author | Lee, Jin Woo | - |
dc.contributor.author | Jang, Dae Sik | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Shim, Sang Hee | - |
dc.date.accessioned | 2023-03-14T00:40:08Z | - |
dc.date.available | 2023-03-14T00:40:08Z | - |
dc.date.created | 2023-03-10 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2470-1343 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87059 | - |
dc.description.abstract | The endophytic fungus Colletotrichum gloeosprioides JS0419, isolated from the leaves of the halophyte Suaeda japonica, produced four new beta-resorcylic acid derivatives, colletogloeopyrones A and B (1 and 2) and colletogloeolactones A and B (3 and 4), and seven known beta-resorcylic acid lactones (RALs). The structures of these compounds were elucidated via analysis of the high-resolution mass spectrometry and nuclear magnetic resonance data. Compounds 1 and 2 showed a dihydrobenzopyranone ring with a linear C9 side chain, which is rarely observed in RALs. All isolated compounds were evaluated for their anti-inflammatory activities. Colletogloeopyrone A (1), monocillin II (5), and monocillin II glycoside (6) were effective in reducing nitric oxide production without cytotoxicity. They also inhibited the secretion of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), as demonstrated by the expression of mRNA corresponding to IL-6 and TNF-alpha. Mechanistically, compounds 5 and 6 significantly inhibited the protein expression of nuclear factor-kappa B, I kappa B alpha, IKK alpha/beta, inducible nitric oxide synthase, and cyclooxygenase (COX)-2, whereas compound 1 only inhibited COX-2 expression. This study indicated that RAL-type compounds 1, 5, and 6 demonstrated potential anti-inflammatory activity by inhibiting the synthesis of pro-inflammatory cytokines. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS OMEGA | - |
dc.title | New Anti-Inflammatory beta-Resorcylic Acid Lactones Derived from an Endophytic Fungus, Colletotrichum sp. | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000926734100001 | - |
dc.identifier.doi | 10.1021/acsomega.2c07962 | - |
dc.identifier.bibliographicCitation | ACS OMEGA, v.8, no.3, pp.3530 - 3538 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85146393742 | - |
dc.citation.endPage | 3538 | - |
dc.citation.startPage | 3530 | - |
dc.citation.title | ACS OMEGA | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Baek, Ji Yun | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | A-E | - |
dc.subject.keywordPlus | FUNGUS | - |
dc.subject.keywordPlus | DIASTEREOISOMERS | - |
dc.subject.keywordPlus | STEREOCHEMISTRY | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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