Tryptophan-dependent and-independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tram Thuy Thuy Nguyen | - |
dc.contributor.author | Choi, Yun Hui | - |
dc.contributor.author | Lee, Won-Kyu | - |
dc.contributor.author | Ji, Yeounjung | - |
dc.contributor.author | Chun, Eunho | - |
dc.contributor.author | Kim, Yi Hyo | - |
dc.contributor.author | Lee, Joo-Eun | - |
dc.contributor.author | Jung, Hyun Suk | - |
dc.contributor.author | Suh, Ji Hun | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.contributor.author | Jin, Mirim | - |
dc.date.accessioned | 2023-03-14T06:40:20Z | - |
dc.date.available | 2023-03-14T06:40:20Z | - |
dc.date.created | 2023-03-14 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87076 | - |
dc.description.abstract | While cytoplasmic tryptophanyl-tRNA synthetase (WARS1) ligates tryptophan (Trp) to its cognate tRNAs for protein synthesis, it also plays a role as an innate immune activator in extracellular space. However, its secre-tion mechanism remains elusive. Here, we report that in response to stimuli, WARS1 can be secreted via two distinct pathways: via Trp-dependent secretion of naked protein and via Trp-independent plasma -mem-brane-derived vesicles (PMVs). In the direct pathway, Trp binding to WARS1 induces a "closed"conforma-tion, generating a hydrophobic surface and basic pocket. The Trp-bound WARS1 then binds stable phospha-tidylinositol (4,5)-biphosphate and inner plasma membrane leaflet, passing across the membrane. In the PMV-mediated secretion, WARS1 recruits calpain 2, which is activated by calcium. WARS1 released from PMVs induces inflammatory responses in vivo. These results provide insights into the secretion mechanisms of WARS1 and improve our understanding of how WARS1 is involved in the control of local and systemic inflammation upon infection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.title | Tryptophan-dependent and-independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000921153500001 | - |
dc.identifier.doi | 10.1016/j.celrep.2022.111905 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.42, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85145201634 | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Tram Thuy Thuy Nguyen | - |
dc.contributor.affiliatedAuthor | Choi, Yun Hui | - |
dc.contributor.affiliatedAuthor | Ji, Yeounjung | - |
dc.contributor.affiliatedAuthor | Chun, Eunho | - |
dc.contributor.affiliatedAuthor | Kim, Yi Hyo | - |
dc.contributor.affiliatedAuthor | Jin, Mirim | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | calpain 2 | - |
dc.subject.keywordAuthor | CP: Immunology | - |
dc.subject.keywordAuthor | CP: Molecular biology | - |
dc.subject.keywordAuthor | innate immune response | - |
dc.subject.keywordAuthor | phosphatidylinositol (4,5)-biphosphate | - |
dc.subject.keywordAuthor | plasma membrane-derived vesicles | - |
dc.subject.keywordAuthor | tryptophan | - |
dc.subject.keywordAuthor | tryptophanyl-tRNA synthetase | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CALPAIN | - |
dc.subject.keywordPlus | ATP | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | VESICLES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | ROLES | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.