Biopsy-Integrated 3D Magnetic Resonance Imaging Modeling of Prostate Cancer and Its Application for Gleason Grade and Tumor Laterality Assessment
DC Field | Value | Language |
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dc.contributor.author | Kim, Jisup | - |
dc.contributor.author | Lim, Bumjin | - |
dc.contributor.author | Jeong, In Gab | - |
dc.contributor.author | Ro, Jae Y. | - |
dc.contributor.author | Go, Heounjeong | - |
dc.contributor.author | Cho, Yong Mee | - |
dc.contributor.author | Park, Kye Jin | - |
dc.date.accessioned | 2023-03-14T07:40:23Z | - |
dc.date.available | 2023-03-14T07:40:23Z | - |
dc.date.created | 2023-03-13 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0003-9985 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87101 | - |
dc.description.abstract | center dot Context.-Grade Group assessed using Gleason com-bined score and tumor extent is a main determinant for risk stratification and therapeutic planning of prostate cancer. Objective.-To develop a 3-dimensional magnetic reso-nance imaging (MRI) model regarding Grade Group and tumor extent in collaboration with uroradiologists and uropathologists for optimal treatment planning for prostate cancer. Design.-We studied the data from 83 patients with prostate cancer who underwent multiparametric MRI and subsequent MRI-transrectal ultrasound fusion biopsy and radical prostatectomy. A 3-dimensional MRI model was constructed by integrating topographic information of MRI-based segmented lesions, biopsy paths, and histopath-ologic information of biopsy specimens. The multipara-metric MRI-integrated Grade Group and laterality were assessed by using the 3-dimensional MRI model and compared with the radical prostatectomy specimen. Results.-The MRI-defined index tumor was concordant with radical prostatectomy in 94.7% (72 of 76) of cases. The multiparametric MRI-integrated Grade Group re -vealed the highest agreement (weighted j, 0.545) and a significantly higher concordance rate (57.9%) than the targeted (47.8%, P = .008) and systematic (39.4%, P= .01) biopsies. The multiparametric MRI-integrated Grade Group showed significantly less downgrading rates than the combined biopsy (P = .001), without significant differences in upgrading rate (P = .06). The 3-dimensional multiparametric MRI model estimated tumor laterality in 66.2% (55 of 83) of cases, and contralateral clinically significant cancer was missed in 9.6% (8 of 83) of cases. The tumor length measured by multiparametric MRI best correlated with radical prostatectomy as compared with the biopsy-defined length. Conclusions.-The 3-dimensional model incorporating MRI and MRI-transrectal ultrasound fusion biopsy infor-mation easily recognized the spatial distribution of MRI-visible and MRI-nonvisible cancer and provided better Grade Group correlation with radical prostatectomy specimens but still requires validation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | COLL AMER PATHOLOGISTS | - |
dc.relation.isPartOf | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | - |
dc.title | Biopsy-Integrated 3D Magnetic Resonance Imaging Modeling of Prostate Cancer and Its Application for Gleason Grade and Tumor Laterality Assessment | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000928165600006 | - |
dc.identifier.doi | 10.5858/arpa.2021-0256-OA | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, v.147, no.2, pp.159 - 166 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85147047042 | - |
dc.citation.endPage | 166 | - |
dc.citation.startPage | 159 | - |
dc.citation.title | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | - |
dc.citation.volume | 147 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Kim, Jisup | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ISUP CONSENSUS CONFERENCE | - |
dc.subject.keywordPlus | INTERNATIONAL-SOCIETY | - |
dc.subject.keywordPlus | DISCONTINUOUS FOCI | - |
dc.subject.keywordPlus | TARGETED BIOPSY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CORE | - |
dc.subject.keywordPlus | CORRELATE | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | VOLUME | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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