(1' S)-1'-Acetoxyeugenol Acetate Enhances Glucose-Stimulated Insulin Secretion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Son, So-Ri | - |
dc.contributor.author | Qi, Yutong | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Jang, Dae Sik | - |
dc.date.accessioned | 2023-03-14T07:40:30Z | - |
dc.date.available | 2023-03-14T07:40:30Z | - |
dc.date.created | 2023-03-10 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 2223-7747 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87107 | - |
dc.description.abstract | Alpinia galanga have been widely used as spice or traditional medicine in East Asia, commonly known as Thai ginger. In the present study, seven major phenylpropanoids, (+/-)-1 '-hydoxychavicol acetate (1; HCA), (1 ' S)-1 '-acetoxychavicol acetate (2; ACA), (1 ' S)-1 '-acetoxyeugenol acetate (3; AEA), eugenyl acetate (4), trans-p-coumaraldehyde (5), trans-p-acetoxycinnamyl alcohol (6), and trans-p-coumaryl diacetate (7), were isolated from the 95% EtOH and hot water extracts of the rhizomes of A. galanga by chromatographic method. Phenylpropanoids 1-7 were evaluated for glucose-stimulated insulin secretion (GSIS) effect and oc-glucosidase inhibitory activity.Phenylpropanoids 1-4 increase GSIS effect without cytotoxicity in rat INS-1 pancreatic beta-cells. In addition, INS-1 cells were treated with AEA (3) to determine a plausible mechanism of beta-cell function and insulin secretion through determining the activation of insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and pancreatic and duodenal homeobox-1 (PDX-1). Upon treatment with AEA (3), INS-1 cells showed an increase in these protein expressions. Meanwhile, AEA (3) exhibited oc-glucosidase inhibitory activity. On the basis of the above findings, we suggest AEA (3) as a potential antidiabetic agent. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | PLANTS-BASEL | - |
dc.title | (1' S)-1'-Acetoxyeugenol Acetate Enhances Glucose-Stimulated Insulin Secretion | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000930156800001 | - |
dc.identifier.doi | 10.3390/plants12030579 | - |
dc.identifier.bibliographicCitation | PLANTS-BASEL, v.12, no.3 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85147978386 | - |
dc.citation.title | PLANTS-BASEL | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alpinia galanga | - |
dc.subject.keywordAuthor | (1&apos | - |
dc.subject.keywordAuthor | S)-1&apos | - |
dc.subject.keywordAuthor | -acetoxyeugenol acetate | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordAuthor | alpha-glucosidase | - |
dc.subject.keywordAuthor | PDX-1 | - |
dc.subject.keywordPlus | BETA-CELL SURVIVAL | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | ALPINIA-GALANGA | - |
dc.subject.keywordPlus | 1&apos | - |
dc.subject.keywordPlus | -ACETOXYCHAVICOL ACETATE | - |
dc.subject.keywordPlus | ALPHA-GLUCOSIDASE | - |
dc.subject.keywordPlus | SECRETAGOGUES | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | ACIDS | - |
dc.subject.keywordPlus | ACA | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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