Pseudomonas stutzeri PM101005 inhaled with atmospheric particulate matter induces lung damage through inflammatory responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Yu-Jin | - |
dc.contributor.author | Kim, Chang-Ung | - |
dc.contributor.author | Lee, Kyung-Soo | - |
dc.contributor.author | Kim, Ji Hyung | - |
dc.contributor.author | Park, Seo Young | - |
dc.contributor.author | Jeong, Ahn Young | - |
dc.contributor.author | Lee, Jun Bong | - |
dc.contributor.author | Kim, Doo-Jin | - |
dc.contributor.author | Park, Young-Jun | - |
dc.contributor.author | Lee, Moo-Seung | - |
dc.date.accessioned | 2023-03-14T07:40:35Z | - |
dc.date.available | 2023-03-14T07:40:35Z | - |
dc.date.created | 2023-03-13 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 0269-7491 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87113 | - |
dc.description.abstract | Atmospheric particulate matter (PM) contains a mixture of chemical and biological elements that pose threat to human health by increasing susceptibility to respiratory diseases. Although the identification of the microorganisms composing the PM has been assessed, their immunological impacts are still questionable. Here, we examined the mechanisms responsible for the pathogenicity of Pseudomonas stutzeri PM101005 (PMPS), a bacterium isolated from fine dust, in lung epithelial cells, alveolar cells, and macrophages. Relative to its comparative strain Pseudomonas stutzeri (PS), infections with PMPS induced higher production of inflammatory cytokines and chemokines, mediated by the activation of NF-kappa B and MAPK signaling pathways. Additionally, with three-dimensional (3D) airway spheroids which mimic the human bronchial epithelium, we confirmed that PMPS infections lead to relatively higher induction of pro-inflammatory cytokines than PM infections. Consistent results were observed in murine models as the infections with PMPS provoked greater inflammatory responses than the infections with PS. These PMPS-induced responses were mediated by the signaling pathways of the Toll-like receptors (TLRs), which regulated PMPS infection and played an important role in the expression of the antibiotic peptide beta-defensin 3 (BD3) that suppressed PMPS proliferation. Moreover, PM pretreatment enhanced inflammatory responses and tissue damage of PMPS, while reducing BD3 expression. Overall, these results indicate that PM-isolated PMPS induce TLR-mediated inflammatory responses in lung tissues, and contributes to the understanding of the etiology of PM-induced respiratory damage. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | ENVIRONMENTAL POLLUTION | - |
dc.title | Pseudomonas stutzeri PM101005 inhaled with atmospheric particulate matter induces lung damage through inflammatory responses | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000928222500004 | - |
dc.identifier.doi | 10.1016/j.envpol.2022.120741 | - |
dc.identifier.bibliographicCitation | ENVIRONMENTAL POLLUTION, v.317 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85142685104 | - |
dc.citation.title | ENVIRONMENTAL POLLUTION | - |
dc.citation.volume | 317 | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Particulate matter | - |
dc.subject.keywordAuthor | Respiratory diseases | - |
dc.subject.keywordAuthor | Lungs | - |
dc.subject.keywordAuthor | Pseudomonas stutzeri | - |
dc.subject.keywordAuthor | Inflammatory response | - |
dc.subject.keywordPlus | AIR-POLLUTION | - |
dc.subject.keywordPlus | HOSPITAL ADMISSIONS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | POLLUTANTS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | COMPONENTS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.