BioMatrix Versus Orsiro Stents for Coronary Artery Disease: A Multicenter, Randomized, Open-Label Study
DC Field | Value | Language |
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dc.contributor.author | Yoon, Chang-Hwan | - |
dc.contributor.author | Kwun, Ju-Seung | - |
dc.contributor.author | Choi, Young Jin | - |
dc.contributor.author | Park, Jin Joo | - |
dc.contributor.author | Kang, Si-Hyuck | - |
dc.contributor.author | Kim, Sun-Hwa | - |
dc.contributor.author | Suh, Jung-Won | - |
dc.contributor.author | Youn, Tae-Jin | - |
dc.contributor.author | Kim, Myeong-Kon | - |
dc.contributor.author | Cha, Kwang Soo | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.contributor.author | Hong, Bum-Kee | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Kang, Woong Chol | - |
dc.contributor.author | Lee, Jae-Hwan | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.contributor.author | Chae, In-Ho | - |
dc.date.accessioned | 2023-03-14T07:40:41Z | - |
dc.date.available | 2023-03-14T07:40:41Z | - |
dc.date.created | 2023-03-13 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1941-7640 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87115 | - |
dc.description.abstract | Background: Comparative studies of ultrathin-strut biodegradable polymer sirolimus-eluting stent (BP-SES) have reported promising results and validated its excellent outcomes in terms of safety and efficacy. However, there are limited studies comparing BP drug-eluting stents with struts of different thicknesses. We compared the long-term clinical outcomes of patients treated with an ultrathin-strut BP-SES or a thick-strut biodegradable polymer biolimus-eluting stent (BP-BES).Methods: The BIODEGRADE trial (Biomatrix and Orsiro Drug-Eluting Stents in Angiographic Result in Patients With Coronary Artery Disease) is a multicenter prospective randomized study comparing coronary revascularization in patients with ultrathin-strut BP-SES and thick-strut BP-BES with the primary end point of target lesion failure at 18 months posttreatment. We performed the prespecified analysis of 3-year clinical outcomes.Results: In total, 2341 patients were randomized to receive treatment with ultrathin-strut BP-SES (N=1175) or thick-strut BP-BES (N=1166). The 3-year incidence rate of target lesion failure was 3.2% for BP-SES and 5.1% for BP-BES (P=0.023). The difference was primarily due to differences in ischemia-driven target lesion revascularization (BP-SES, 1.5%; BP-BES, 2.8%; P=0.035) between groups. A landmark analysis of the late follow-up period showed significant differences in target lesion failure, with outcomes being better in BP-SES. Cardiac death and target lesion revascularization were significantly lower in the BP-SES group.Conclusions: In a large, randomized trial, the long-term clinical outcome of target lesion failure at 3 years was significantly better among patients treated with the ultrathin-strut BP-SES. The results indicate the superiority of the ultrathin-strut BP-SES compared with the thick-strut BP-BES.Registration: URL: ; Unique identifier: NCT02299011. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.title | BioMatrix Versus Orsiro Stents for Coronary Artery Disease: A Multicenter, Randomized, Open-Label Study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000923297300001 | - |
dc.identifier.doi | 10.1161/CIRCINTERVENTIONS.122.012307 | - |
dc.identifier.bibliographicCitation | CIRCULATION-CARDIOVASCULAR INTERVENTIONS, v.16, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85146408786 | - |
dc.citation.title | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kang, Woong Chol | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | coronary artery disease | - |
dc.subject.keywordAuthor | drug-eluting stent | - |
dc.subject.keywordAuthor | ischemia | - |
dc.subject.keywordAuthor | percutaneous coronary intervention | - |
dc.subject.keywordAuthor | sirolimus | - |
dc.subject.keywordPlus | SIROLIMUS-ELUTING STENTS | - |
dc.subject.keywordPlus | DURABLE POLYMER | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | INTERVENTION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | CYPHER | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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