MARS2 drives metabolic switch of non-small-cell lung cancer cells via interaction with MCU
DC Field | Value | Language |
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dc.contributor.author | Son, Juhyeon | - |
dc.contributor.author | Jung, Okkeun | - |
dc.contributor.author | Kim, Jong Heon | - |
dc.contributor.author | Park, Kyu Sang | - |
dc.contributor.author | Kweon, Hee-Seok | - |
dc.contributor.author | Nguyen, Nhung Thi | - |
dc.contributor.author | Lee, Yu Jin | - |
dc.contributor.author | Cha, Hansol | - |
dc.contributor.author | Lee, Yejin | - |
dc.contributor.author | Tran, Quangdon | - |
dc.contributor.author | Seo, Yoona | - |
dc.contributor.author | Park, Jongsun | - |
dc.contributor.author | Choi, Jungwon | - |
dc.contributor.author | Cheong, Heesun | - |
dc.contributor.author | Lee, Sang Yeol | - |
dc.date.accessioned | 2023-03-18T01:40:09Z | - |
dc.date.available | 2023-03-18T01:40:09Z | - |
dc.date.created | 2023-03-18 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 2213-2317 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87154 | - |
dc.description.abstract | Mitochondrial methionyl-tRNA synthetase (MARS2) canonically mediates the formation of fMet-tRNAifMet for mitochondrial translation initiation. Mitochondrial calcium uniporter (MCU) is a major gate of Ca2+ flux from cytosol into the mitochondrial matrix. We found that MARS2 interacts with MCU and stimulates mitochondrial Ca2+ influx. Methionine binding to MARS2 would act as a molecular switch that regulates MARS2-MCU inter-action. Endogenous knockdown of MARS2 attenuates mitochondrial Ca2+ influx and induces p53 upregulation through the Ca2+-dependent CaMKII/CREB signaling. Subsequently, metabolic rewiring from glycolysis into pentose phosphate pathway is triggered and cellular reactive oxygen species level decreases. This metabolic switch induces inhibition of epithelial-mesenchymal transition (EMT) via cellular redox regulation. Expression of MARS2 is regulated by ZEB1 transcription factor in response to Wnt signaling. Our results suggest the mecha-nisms of mitochondrial Ca2+ uptake and metabolic control of cancer that are exerted by the key factors of the mitochondrial translational machinery and Ca2+ homeostasis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | REDOX BIOLOGY | - |
dc.title | MARS2 drives metabolic switch of non-small-cell lung cancer cells via interaction with MCU | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000944330600001 | - |
dc.identifier.doi | 10.1016/j.redox.2023.102628 | - |
dc.identifier.bibliographicCitation | REDOX BIOLOGY, v.60 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85147885986 | - |
dc.citation.title | REDOX BIOLOGY | - |
dc.citation.volume | 60 | - |
dc.contributor.affiliatedAuthor | Son, Juhyeon | - |
dc.contributor.affiliatedAuthor | Jung, Okkeun | - |
dc.contributor.affiliatedAuthor | Lee, Yu Jin | - |
dc.contributor.affiliatedAuthor | Cha, Hansol | - |
dc.contributor.affiliatedAuthor | Lee, Yejin | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeol | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Mitochondrial methionyl-tRNA synthetase | - |
dc.subject.keywordAuthor | Mitochondrial calcium uniporter | - |
dc.subject.keywordAuthor | Cancer metabolism | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Epithelial-mesenchymal transition | - |
dc.subject.keywordPlus | TRANSFER-RNA SYNTHETASE | - |
dc.subject.keywordPlus | MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | CONFORMATIONAL-CHANGES | - |
dc.subject.keywordPlus | MITOCHONDRIAL CA2+ | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | METHIONINE | - |
dc.subject.keywordPlus | UNIPORTER | - |
dc.subject.keywordPlus | KINASES | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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