Phytochemicals That Act on Synaptic Plasticity as Potential Prophylaxis against Stress-Induced Depressive Disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Soojung | - |
dc.contributor.author | Iqbal, Hamid | - |
dc.contributor.author | Kim, Sun Mi | - |
dc.contributor.author | Jin, Mirim | - |
dc.date.accessioned | 2023-03-27T00:40:41Z | - |
dc.date.available | 2023-03-27T00:40:41Z | - |
dc.date.created | 2023-02-28 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87239 | - |
dc.description.abstract | Depression is a neuropsychiatric disorder associated with persistent stress and disruption of neuronal function. Persistent stress causes neuronal atrophy, including loss of synapses and reduced size of the hippocampus and prefrontal cortex. These alterations are associated with neural dysfunction, including mood disturbances, cognitive impairment, and behavioral changes. Synaptic plasticity is the fundamental function of neural networks in response to various stimuli and acts by reorganizing neuronal structure, function, and connections from the molecular to the behavioral level. In this review, we describe the alterations in synaptic plasticity as underlying pathological mechanisms for depression in animal models and humans. We further elaborate on the significance of phytochemicals as bioactive agents that can positively modulate stress-induced, aberrant synaptic activity. Bioactive agents, including flavonoids, terpenes, saponins, and lignans, have been reported to upregulate brain-derived neurotrophic factor expression and release, suppress neuronal loss, and activate the relevant signaling pathways, including TrkB, ERK, Akt, and mTOR pathways, resulting in increased spine maturation and synaptic numbers in the neuronal cells and in the brains of stressed animals. In clinical trials, phytochemical usage is regarded as safe and well-tolerated for suppressing stress-related parameters in patients with depression. Thus, intake of phytochemicals with safe and active effects on synaptic plasticity may be a strategy for preventing neuronal damage and alleviating depression in a stressful life. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국응용약물학회 | - |
dc.relation.isPartOf | Biomolecules & Therapeutics | - |
dc.title | Phytochemicals That Act on Synaptic Plasticity as Potential Prophylaxis against Stress-Induced Depressive Disorder | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000944174600002 | - |
dc.identifier.doi | 10.4062/biomolther.2022.116 | - |
dc.identifier.bibliographicCitation | Biomolecules & Therapeutics, v.31, no.2, pp.148 - 160 | - |
dc.identifier.kciid | ART002931873 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85150026364 | - |
dc.citation.endPage | 160 | - |
dc.citation.startPage | 148 | - |
dc.citation.title | Biomolecules & Therapeutics | - |
dc.citation.volume | 31 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Yoon, Soojung | - |
dc.contributor.affiliatedAuthor | Iqbal, Hamid | - |
dc.contributor.affiliatedAuthor | Jin, Mirim | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Stress | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Synaptic plasticity | - |
dc.subject.keywordAuthor | Phytochemicals | - |
dc.subject.keywordAuthor | Preventive agents | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR EXPRESSION | - |
dc.subject.keywordPlus | MAJOR DEPRESSION | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | STRUCTURAL PLASTICITY | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | DENDRITIC SPINES | - |
dc.subject.keywordPlus | CINGULATE CORTEX | - |
dc.subject.keywordPlus | GINSENOSIDE RG1 | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.