사상자의 세포자기살해능이 자궁경부암세포에 미치는 영향Effects of Apoptosis of Torilis Japonica on Cervical Cancer Cell
- Other Titles
- Effects of Apoptosis of Torilis Japonica on Cervical Cancer Cell
- Authors
- 권나연; 김기봉; 박장경; 안상현
- Issue Date
- Feb-2023
- Publisher
- 대한한방부인과학회
- Keywords
- Torilis Japonica; Cervical Cancer; Apoptosis; Anti-cancer Activity
- Citation
- 대한한방부인과학회지, v.36, no.1, pp.23 - 34
- Journal Title
- 대한한방부인과학회지
- Volume
- 36
- Number
- 1
- Start Page
- 23
- End Page
- 34
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87246
- DOI
- 10.15204/jkobgy.2023.36.1.023
- ISSN
- 1229-4292
- Abstract
- Objectives: This study was conducted to confirm the anticancer effect of Torilis Japonica (TJ) on cervical cancer and to determine whether the effect was apoptosis.
Methods: In this study, the effect of TJ extract on toxicity, mitochondrial morphology, nuclear morphological changes, Extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathway were investigated in HeLa cell, human cervical cancer cell.
Results: The cytotoxicity, ratio of cells with nuclear changes to the total number of cells, and P38 phosphorylation increased in a concentration-dependent manner after administration of TJ extract. The length of mitochondria and ERK phosphorylation in HeLa cells decreased in a concentration-dependent manner after administration of TJ extract.
Conclusions: TJ extract has an anticancer effect on cervical cancer cells, which is presumed to be due to apoptosis, and showed potential as a future cervical cancer treatment.
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