바이칼레인(baicalein)이 peptidoglycan으로 자극된 RAW 264.7 mouse macrophages의 hydrogen peroxide 생성에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 박완수 | - |
dc.date.accessioned | 2023-03-27T00:42:06Z | - |
dc.date.available | 2023-03-27T00:42:06Z | - |
dc.date.created | 2023-03-24 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87264 | - |
dc.description.abstract | Objectives : The aim of this study was to investigate the effect of baicalein (BA) on the production of hydrogen peroxide in peptidoglycan-stimulated RAW 264.7 mouse macrophages. Methods : Peptidoglycan-stimulated RAW 264.7 were incubated with baicalein at concentrations of 50 and 100 µM. Incubation time is 30 min, 2 h, 12 h, and 18 h. After incubation, The production of hydrogen peroxide in RAW 264.7 was measured with dihydrorhodamine 123 assay. Berberine and gallic acid were used as the comparative materials. Results : BA at the concentration of 50 and 100 µM did not show cytotoxicity on RAW 264.7 for 24 h incubation. For 30 min, 2 h, 12 h, and 18 h incubation, BA at the concentration of 50 and 100 µM significantly inhibited the production of hydrogen peroxide in RAW 264.7 stimulated by peptidoglycan (p < 0.05). In details, production of hydrogen peroxide in peptidoglycan-stimulated RAW 264.7 treated for 30 min with BA at concentrations of 50 and 100 µM was 93.91% and 93.52% of the control group treated with peptidoglycan only, respectively; the production of hydrogen peroxide for 2 h was 93.8% and 92.71%, respectively; production of hydrogen peroxide for 12 h was 94.86% and 95.93%, respectively; production of hydrogen peroxide for 18 h was 95.37% and 96.48%, respectively. Conclusions : BA might have anti-oxidative activity related to its inhibition of hydrogen peroxide production in peptidoglycan-stimulated RAW 264.7 macrophages. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | 바이칼레인(baicalein)이 peptidoglycan으로 자극된 RAW 264.7 mouse macrophages의 hydrogen peroxide 생성에 미치는 영향 | - |
dc.title.alternative | Effects of Baicalein on hydrogen peroxide productions in RAW 264.7 mouse macrophages stimulated by peptidoglycan | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.38, no.1, pp.1 - 9 | - |
dc.identifier.kciid | ART002926793 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | 박완수 | - |
dc.subject.keywordAuthor | RAW 264.7 | - |
dc.subject.keywordAuthor | Baicalein | - |
dc.subject.keywordAuthor | Macrophage | - |
dc.subject.keywordAuthor | Peptidoglycan | - |
dc.subject.keywordAuthor | Hydrogen peroxide | - |
dc.description.journalRegisteredClass | kci | - |
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