Hierarchical Au nanoclusters electrodeposited on amine-terminated ITO glass as a SERS-active substrate for the reliable and sensitive detection of serotonin in a Tris-HCl buffer solution
DC Field | Value | Language |
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dc.contributor.author | Viet-Duc Phung | - |
dc.contributor.author | Kook, Jeong-Keun | - |
dc.contributor.author | Koh, Do Yeung | - |
dc.contributor.author | Lee, Sang-Wha | - |
dc.date.available | 2020-02-27T02:20:59Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-11-14 | - |
dc.identifier.issn | 1477-9226 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/872 | - |
dc.description.abstract | Although serotonin (5-HT) is one of the most important neurotransmitters that are responsible for critical roles in the central nervous system, only few studies have been reported on the reliable and sensitive detection of 5-HT by the SERS technique owing to the lower Raman cross-section and lack of a common extraction method of 5-HT. In this study, a SERS-active substrate was fabricated by electrodepositing hierarchical Au nanostructures on amine-terminated ITO (indium tin oxide) glass to achieve an enhanced Raman signal of 5-HT. The electrodeposition process was performed by applying the nucleation potential E-1 = 0.7 V for 2 s and the growth potential E-2 = -0.2 V for 1000 s for repeated cycles. As a testing analyte, 5-HT was dissolved in four different solvents i.e. PBS buffer, Tris-HCl buffer, distilled water, and ethanol solution (20%). Among them, Tris-HCl buffer produced the most sensitive and reproducible Raman signals for 5-HT along with the lowest detection limit of similar to 10(-9) M due to the strong adsorption interactions between the Au surface and the indole amine groups of 5-HT under alkaline conditions. Surprisingly, the standard curve between the Raman intensity at 751 cm(-1) and the log-scale concentration of 5-HT showed a linear dynamic range of over five orders of magnitude in the Tris-HCl buffer solution, suggesting a possible quantification of the 5-HT level in a biological fluid with 5-HT dysfunction or deficiency. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | DALTON TRANSACTIONS | - |
dc.subject | PERFORMANCE LIQUID-CHROMATOGRAPHY | - |
dc.subject | ENHANCED RAMAN-SPECTROSCOPY | - |
dc.subject | PLATELET-POOR PLASMA | - |
dc.subject | GOLD NANOPARTICLES | - |
dc.subject | ELECTROCHEMICAL DETECTION | - |
dc.subject | DOPAMINE | - |
dc.subject | NANOSTRUCTURES | - |
dc.subject | NORADRENALINE | - |
dc.subject | DEPENDENCE | - |
dc.subject | MONOLAYERS | - |
dc.title | Hierarchical Au nanoclusters electrodeposited on amine-terminated ITO glass as a SERS-active substrate for the reliable and sensitive detection of serotonin in a Tris-HCl buffer solution | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000493493400028 | - |
dc.identifier.doi | 10.1039/c9dt03269j | - |
dc.identifier.bibliographicCitation | DALTON TRANSACTIONS, v.48, no.42, pp.16026 - 16033 | - |
dc.identifier.scopusid | 2-s2.0-85074242993 | - |
dc.citation.endPage | 16033 | - |
dc.citation.startPage | 16026 | - |
dc.citation.title | DALTON TRANSACTIONS | - |
dc.citation.volume | 48 | - |
dc.citation.number | 42 | - |
dc.contributor.affiliatedAuthor | Viet-Duc Phung | - |
dc.contributor.affiliatedAuthor | Kook, Jeong-Keun | - |
dc.contributor.affiliatedAuthor | Koh, Do Yeung | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Wha | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PERFORMANCE LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | ENHANCED RAMAN-SPECTROSCOPY | - |
dc.subject.keywordPlus | PLATELET-POOR PLASMA | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | ELECTROCHEMICAL DETECTION | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordPlus | NORADRENALINE | - |
dc.subject.keywordPlus | DEPENDENCE | - |
dc.subject.keywordPlus | MONOLAYERS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Inorganic & Nuclear | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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