Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Yeon Sik | - |
dc.contributor.author | Hsueh, Yuan-Yu | - |
dc.contributor.author | Koo, Jahyun | - |
dc.contributor.author | Yang, Quansan | - |
dc.contributor.author | Avila, Raudel | - |
dc.contributor.author | Hu, Buwei | - |
dc.contributor.author | Xie, Zhaoqian | - |
dc.contributor.author | Lee, Geumbee | - |
dc.contributor.author | Ning, Zheng | - |
dc.contributor.author | Liu, Claire | - |
dc.contributor.author | Xu, Yameng | - |
dc.contributor.author | Lee, Young Joong | - |
dc.contributor.author | Zhao, Weikang | - |
dc.contributor.author | Fang, Jun | - |
dc.contributor.author | Deng, Yujun | - |
dc.contributor.author | Lee, Seung Min | - |
dc.contributor.author | Vazquez-Guardado, Abraham | - |
dc.contributor.author | Stepien, Iwona | - |
dc.contributor.author | Yan, Ying | - |
dc.contributor.author | Song, Joseph W. | - |
dc.contributor.author | Haney, Chad | - |
dc.contributor.author | Oh, Yong Suk | - |
dc.contributor.author | Liu, Wentai | - |
dc.contributor.author | Yun, Hong-Joon | - |
dc.contributor.author | Banks, Anthony | - |
dc.contributor.author | MacEwan, Matthew R. | - |
dc.contributor.author | Ameer, Guillermo A. | - |
dc.contributor.author | Ray, Wilson Z. | - |
dc.contributor.author | Huang, Yonggang | - |
dc.contributor.author | Xie, Tao | - |
dc.contributor.author | Franz, Colin K. | - |
dc.contributor.author | Li, Song | - |
dc.contributor.author | Rogers, John A. | - |
dc.date.accessioned | 2023-03-27T08:40:47Z | - |
dc.date.available | 2023-03-27T08:40:47Z | - |
dc.date.created | 2023-03-27 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87371 | - |
dc.description.abstract | Bioresorbable electronic stimulators are of rapidly growing interest as unusual therapeutic platforms, i.e., bioelectronic medicines, for treating disease states, accelerating wound healing processes and eliminating infections. Here, we present advanced materials that support operation in these systems over clinically relevant timeframes, ultimately bioresorbing harmlessly to benign products without residues, to eliminate the need for surgical extraction. Our findings overcome key challenges of bioresorbable electronic devices by realizing lifetimes that match clinical needs. The devices exploit a bioresorbable dynamic covalent polymer that facilitates tight bonding to itself and other surfaces, as a soft, elastic substrate and encapsulation coating for wireless electronic components. We describe the underlying features and chemical design considerations for this polymer, and the biocompatibility of its constituent materials. In devices with optimized, wireless designs, these polymers enable stable, long-lived operation as distal stimulators in a rat model of peripheral nerve injuries, thereby demonstrating the potential of programmable long-term electrical stimulation for maintaining muscle receptivity and enhancing functional recovery. Bioresorbable electronic stimulators can deliver electrical stimulation in rodents to enhance functional muscle recovery after nerve injury. Here, the authors present a bioresorbable dynamic covalent polymer that enables reliable, long-lived operation of soft, stretchable devices of this type. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.title | Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000595970400001 | - |
dc.identifier.doi | 10.1038/s41467-020-19660-6 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.11, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85096525977 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Yun, Hong-Joon | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ELECTRICAL-STIMULATION | - |
dc.subject.keywordPlus | TRANSIENT ELECTRONICS | - |
dc.subject.keywordPlus | NERVE REGENERATION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | CONDUIT | - |
dc.subject.keywordPlus | SENSORS | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | SPEED | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.