Identification and mechanism of action of renoprotective constituents from peat moss Sphagnum palustre in cisplatin-induced nephrotoxicity
DC Field | Value | Language |
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dc.contributor.author | Kang, Hee Rae | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Eom, Hee Jeong | - |
dc.contributor.author | Lee, Seoung Rak | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2020-02-28T03:42:51Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8747 | - |
dc.description.abstract | In search for bioactive constituents from natural resources, the ethanol (EtOH) extract of Sphagnum palustre showed significant renoprotective effects against cisplatin-induced damage in kidney cells. Phytochemical investigation of the EtOH extract led to the identification of a new flavonoid, 6-methyl-(2R,35)-alpinone, along with six known flavonoids, four steroids, six triperpenoids, and three fatty acids. Among them, ergosterol peroxide, (3 beta,22E,24S)-3-hydroxy-ergosta-5,22-dien-7-one, and betulinic acid ameliorated cisplatin-induced nephrotoxicity to 80% of the control value at 125, 125 and 50 mu M, respectively. Moreover, the elevated percentage of apoptotic cells by cisplatin was significantly reduced after co-treatment with the EtOH extract of S. palustre and ergosterol peroxide, (3 beta,22E,24S)-3-hydroxy-ergosta-5,22-dien-7-one, and betulinic acid. Upregulated phosphorylation of INK and p38 by cisplatin treatment was markedly decreased after co-treatment with ergosterol peroxide, (3 beta,22E,24S)-3-hydroxy-ergosta-5,22-dien-7-one, and betulinic acid. These results show that blocking the MAPKs signalling cascade plays a critical role in mediating the renoprotective effect of S. palustre. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | JOURNAL OF FUNCTIONAL FOODS | - |
dc.subject | INDUCED RENAL DAMAGE | - |
dc.subject | INDUCED CYTOTOXICITY | - |
dc.subject | IN-VITRO | - |
dc.subject | ACID | - |
dc.subject | HYDROPEROXIDES | - |
dc.subject | FLAVONOIDS | - |
dc.subject | PROTECTION | - |
dc.subject | GINSENG | - |
dc.subject | ANALOGS | - |
dc.subject | LEAVES | - |
dc.title | Identification and mechanism of action of renoprotective constituents from peat moss Sphagnum palustre in cisplatin-induced nephrotoxicity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000375634900032 | - |
dc.identifier.doi | 10.1016/j.jff.2015.11.010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.20, pp.358 - 368 | - |
dc.identifier.scopusid | 2-s2.0-84953439069 | - |
dc.citation.endPage | 368 | - |
dc.citation.startPage | 358 | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Sphagnum palustre | - |
dc.subject.keywordAuthor | Sphagnaceae | - |
dc.subject.keywordAuthor | Flavonoid | - |
dc.subject.keywordAuthor | Structural elucidation | - |
dc.subject.keywordAuthor | Nephrotoxicity | - |
dc.subject.keywordAuthor | MAPKs | - |
dc.subject.keywordPlus | INDUCED RENAL DAMAGE | - |
dc.subject.keywordPlus | INDUCED CYTOTOXICITY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | HYDROPEROXIDES | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | GINSENG | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | LEAVES | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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