Home-Based Physical Activity and Diet Intervention to Improve Physical Function in Advanced Liver Disease: A Randomized Pilot Trial
DC Field | Value | Language |
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dc.contributor.author | Chen, Hui Wei | - |
dc.contributor.author | Ferrando, Arny | - |
dc.contributor.author | White, Michelle G. | - |
dc.contributor.author | Dennis, Richard A. | - |
dc.contributor.author | Xie, Jesse | - |
dc.contributor.author | Pauly, Margaret | - |
dc.contributor.author | Park, Sanghee | - |
dc.contributor.author | Bartter, Thaddeus | - |
dc.contributor.author | Dunn, Michael A. | - |
dc.contributor.author | Ruiz-Margain, Astrid | - |
dc.contributor.author | Kim, W. Ray | - |
dc.contributor.author | Duarte-Rojo, Andres | - |
dc.date.accessioned | 2023-04-17T05:42:54Z | - |
dc.date.available | 2023-04-17T05:42:54Z | - |
dc.date.created | 2023-04-17 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87481 | - |
dc.description.abstract | Introduction A decline in physical function is highly prevalent and a poor prognostic factor in cirrhosis. We assessed the benefits of a home-based physical activity program (HB-PAP) in patients with cirrhosis with a randomized pilot trial. Methods All participants received a personal activity tracker to monitor daily activities and were given 12 g/day of an essential amino acid supplement. The HB-PAP intervention consisted of biweekly counseling sessions to increase physical activity for 12 weeks. Six-minute walk test (6MWT) and cardiopulmonary exercise testing (CPET) assessed changes in aerobic fitness. Different anthropometric measuring tools were used for skeletal muscle and adiposity assessment. Results Seventeen patients (60% male; 29% nonalcoholic steatohepatitis/cryptogenic, 29% hepatitis C, 24% alcohol, 18% other) were randomized, 9 to HB-PAP group. There were no significant differences in MELD-sodium between HB-PAP and controls at baseline or after the 12-week intervention. By the end of study, there was a significant between-group difference in daily step count favoring the active group (2627 [992-4262],p = 0.001), with less sedentary patients in the active group (33-17% vs. 25-43%,p = 0.003). The 6MWT improved in the HB-PAP group (423 +/- 26 m vs. 482 +/- 35 m), while the controls had a nonsignificant drop (418 +/- 26 m vs. 327 +/- 74 m) with a significant between-group difference. CPET did not change. Other than an improvement in psoas muscle index, there were no differences in anthropometry, or in quality of life. Conclusions HB-PAP maintained physical performance and improved aerobic fitness according to 6MWT but not CPET, supporting the use of personal activity trackers to monitor/guide home-based prehabilitation programs in cirrhosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.title | Home-Based Physical Activity and Diet Intervention to Improve Physical Function in Advanced Liver Disease: A Randomized Pilot Trial | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000574060300001 | - |
dc.identifier.doi | 10.1007/s10620-019-06034-2 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, v.65, no.11, pp.3350 - 3359 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85077619311 | - |
dc.citation.endPage | 3359 | - |
dc.citation.startPage | 3350 | - |
dc.citation.title | DIGESTIVE DISEASES AND SCIENCES | - |
dc.citation.volume | 65 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Park, Sanghee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Frailty | - |
dc.subject.keywordAuthor | Sarcopenia | - |
dc.subject.keywordAuthor | Prehabilitation | - |
dc.subject.keywordAuthor | Exercise | - |
dc.subject.keywordPlus | AEROBIC CAPACITY | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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