Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults
DC Field | Value | Language |
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dc.contributor.author | Park, Sanghee | - |
dc.contributor.author | Church, David D. | - |
dc.contributor.author | Azhar, Gohar | - |
dc.contributor.author | Schutzler, Scott E. | - |
dc.contributor.author | Ferrando, Arny A. | - |
dc.contributor.author | Wolfe, Robert R. | - |
dc.date.accessioned | 2023-04-17T05:43:00Z | - |
dc.date.available | 2023-04-17T05:43:00Z | - |
dc.date.created | 2023-04-17 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1550-2783 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87482 | - |
dc.description.abstract | Background We have determined the acute response of protein kinetics to one or two servings (6.3 g and 12.6 g) of a proprietary composition containing free-form essential amino acids (EAA) (3.2 g EAA per serving) and whey protein (2.4 g per serving), as well as the response to consumption of a popular whey-based protein supplement (Gatorade Recover) (17 g; 12.6 g protein). Methods Whole-body rates of protein synthesis, breakdown and net balance (taken to be the anabolic response) were determined using primed-constant infusions of H-2(5)-phenylalnine and H-2(2)-tyrosine. Muscle protein fractional synthetic rate (FSR) was also determined with the H-2(5)-phenylalanine tracer. Results Plasma EAA levels increased following consumption of all beverages, with the greatest response in the high-dose EAA/protein composition. Similarly, the increase in net balance between whole-body protein synthesis and breakdown was greatest following consumption of the high-dose EAA/protein composition, while the low-dose EAA/protein composition and Gatorade Recover induced similar increases in net balance. When the net balance response was normalized for the total amount of product given, the high- and low-dose EAA/protein beverages were approximately 6- and 3-fold more anabolic than the Gatorade Recover, respectively. The greater anabolic response to the EAA/protein composition was due to greater increases in whole-body protein synthesis with both doses, and a markedly greater suppression of whole-body protein breakdown in the high-dose group. Muscle protein FSR after beverage consumption reflected changes in whole-body protein synthesis, with the larger EAA/protein dose significantly increasing FSR. Conclusion We conclude that a composition of a balanced EAA formulation combined with whey protein is highly anabolic as compared to a whey protein-based recovery product, and that the response is dose-dependent. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION | - |
dc.title | Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000520606300001 | - |
dc.identifier.doi | 10.1186/s12970-020-0340-5 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION, v.17, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85079214436 | - |
dc.citation.title | JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Park, Sanghee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Essential amino acids | - |
dc.subject.keywordAuthor | Whey protein | - |
dc.subject.keywordAuthor | Whole body anabolic response | - |
dc.subject.keywordAuthor | Fractional synthetic rate | - |
dc.subject.keywordAuthor | Leucine | - |
dc.subject.keywordAuthor | Stable isotope | - |
dc.subject.keywordPlus | MUSCLE ANABOLISM | - |
dc.subject.keywordPlus | LEUCINE | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | INGESTION | - |
dc.subject.keywordPlus | HYDROLYSATE | - |
dc.subject.keywordPlus | HUMANS | - |
dc.subject.keywordPlus | BOLUS | - |
dc.subject.keywordPlus | MASS | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalResearchArea | Sport Sciences | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Sport Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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