Single-Dose Intramuscular Toxicity Test Using No-Pain Pharmacopuncture in Sprague-Dawley Rats
DC Field | Value | Language |
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dc.contributor.author | Hwang, Ji Hye | - |
dc.contributor.author | Jung, Chul | - |
dc.date.accessioned | 2023-04-24T01:40:08Z | - |
dc.date.available | 2023-04-24T01:40:08Z | - |
dc.date.created | 2023-03-30 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 2093-6966 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87516 | - |
dc.description.abstract | Objectives: This study aimed to evaluate the potential toxicity of a recently developed and clinically used No-Pain pharmacopuncture (NPP) solution. We also assessed the lethal dose of the NPP agent following a single intramuscular injection in Sprague-Dawley (SD) rats. Methods: Animals were divided into two groups: the NPP test material group and the normal saline control group. A single intramuscular injection of the NPP agent (1.0 mL/ animal) was administered to rats of the NPP test material group. The control group rats received the same volume of normal saline. Both female and male rats were included in each group. All rats were monitored for clinical signs and body weight changes for 14 days after administration of the test substance or saline. At the end of the observation period, a gross necropsy was conducted and localized tolerance at the injection site was analyzed. Results: No mortality was observed in the NPP test material and control groups. Moreover, no test substance-related effects were observed on clinical signs, body weight, necropsy findings, and localized tolerance at the injection site. Conclusion: The approximate lethal dose of the NPP agent is greater than 1.0 mL/animal under the conditions used in this study. Additional toxicity evaluations and clinical studies are needed to confirm the safety of NPP use in clinical practice. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한약침학회 | - |
dc.relation.isPartOf | Journal of Pharmacopuncture | - |
dc.title | Single-Dose Intramuscular Toxicity Test Using No-Pain Pharmacopuncture in Sprague-Dawley Rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000972444500008 | - |
dc.identifier.doi | 10.3831/KPI.2023.26.1.86 | - |
dc.identifier.bibliographicCitation | Journal of Pharmacopuncture, v.26, no.1, pp.86 - 93 | - |
dc.identifier.kciid | ART002941580 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85152724825 | - |
dc.citation.endPage | 93 | - |
dc.citation.startPage | 86 | - |
dc.citation.title | Journal of Pharmacopuncture | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Hwang, Ji Hye | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Keywords: safety | - |
dc.subject.keywordAuthor | single intramuscular toxicity | - |
dc.subject.keywordAuthor | No-Pain (Mutong) pharmacopuncture | - |
dc.subject.keywordAuthor | corydalis tube | - |
dc.subject.keywordAuthor | jakyak gamcho decoction | - |
dc.subject.keywordAuthor | shakuyaku-kanzo-to | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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