Lespedeza bicolor extract supplementation reduced hyperglycemia-induced skeletal muscle damage by regulation of AMPK/SIRT/PGC1?-related energy metabolism in type 2 diabetic mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Heaji | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lim, Yunsook | - |
dc.date.accessioned | 2023-05-06T09:40:18Z | - |
dc.date.available | 2023-05-06T09:40:18Z | - |
dc.date.created | 2023-05-06 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87559 | - |
dc.description.abstract | Lespedeza bicolor (LB) is known to have antidiabetic activities; however, the underlying molecular mechanisms of LB in hyperglycemia-induced skeletal muscle damage is unclear. Inflammation and oxidative stress caused by type 2 diabetes mellitus (T2DM) not only contributes to insulin resistance, but also promotes muscle atrophy via decreased mus-cle protein synthesis and increased protein degradation, leading to frailty and sarcope-nia. In this study, we hypothesized that LB extract (LBE) supplementatin has an amelio-rative effect on hyperglycemia-induced skeletal muscle damage by activation of 5 ' adeno-sine monophosphate-activated protein kinase (AMPK)/sirtuin (SIRT)/proliferator-activated receptor gamma coactivator 1 alpha (PGC1 alpha )-associated energy metabolism in mice with T2DM. Dia-betes was induced by a high-fat diet with a 2-time streptozotoxin injection (30 mg/kg body weight) in male C57BL/6J mice. After diabetes was induced (fasting blood glucose level >140 mg/dL), the mice were administered with LBE at a low dose (100 mg/kg/d) or high dose (250 mg/kg/d) by gavage for 12 weeks. LBE supplementation ameliorated glucose tolerance and hemoglobin A1c (%) in mice with T2DM. Moreover, LBE supplementation upregulated pro-tein levels of insulin receptor subunit-1 and Akt accompanied by increased translocation of glucose transporter 4 in mice with T2DM. Furthermore, LBE increased mitochondrial bio-genesis by activating SIRT1, SIRT3, SIRT4, and peroxisome PGC1 alpha in diabetic skeletal mus-cle. Meanwhile, LBE supplementation reduced oxidative stress and inflammation in mice with T2DM. Taken together, the current study suggested that LBE could be a potential ther-apeutic to prevent skeletal muscle damage by regulation AMPK/SIRT/PGC1 alpha-related energy metabolism in T2DM.(c) 2022 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | NUTRITION RESEARCH | - |
dc.title | Lespedeza bicolor extract supplementation reduced hyperglycemia-induced skeletal muscle damage by regulation of AMPK/SIRT/PGC1?-related energy metabolism in type 2 diabetic mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000974888700001 | - |
dc.identifier.doi | 10.1016/j.nutres.2022.12.007 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH, v.110, pp.1 - 13 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85146313551 | - |
dc.citation.endPage | 13 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | NUTRITION RESEARCH | - |
dc.citation.volume | 110 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Lespedeza bicolor | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | Skeletal muscle | - |
dc.subject.keywordAuthor | Insulin signaling | - |
dc.subject.keywordAuthor | Energy metabolism | - |
dc.subject.keywordPlus | IMPROVES GLUCOSE-HOMEOSTASIS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | PGC-1-ALPHA | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | BIOENERGETICS | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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