Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

A small molecule compound that inhibits blue light-induced retinal damage via activation of autophagy

Full metadata record
DC Field Value Language
dc.contributor.authorShin, Chae Young-
dc.contributor.authorLee, Sanha-
dc.contributor.authorJin, Hong Lan-
dc.contributor.authorFei, Xiang-
dc.contributor.authorKang, Sang Won-
dc.contributor.authorSeo, Seung-Yong-
dc.contributor.authorJeong, Kwang Won-
dc.date.accessioned2023-05-16T00:41:05Z-
dc.date.available2023-05-16T00:41:05Z-
dc.date.created2023-05-15-
dc.date.issued2023-05-
dc.identifier.issn0006-2952-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87677-
dc.description.abstractDry age-related macular degeneration (AMD) is a type of disease that causes visual impairment due to changes in the macula located in the center of the retina. The accumulation of drusen under the retina is also a characteristic of dry AMD. In this study, we identified a compound (JS-017) that can potentially degrade N-ret-inylidene-N-retinylethanolamine (A2E), one of the components of lipofuscin, using fluorescence-based screening, which measures A2E degradation in human retinal pigment epithelial cells. JS-017 effectively degraded A2E in ARPE-19 cells and consequently suppressed the activation of the NF-?B signaling pathway and expression of inflammatory and apoptosis genes induced by blue light (BL). Mechanistically, JS-017 induced LC3-II formation and improved autophagic flux in ARPE-19 cells. Additionally, the A2E degradation activity of JS-017 was found to be decreased in autophagy-related 5 protein-depleted ARPE-19 cells, suggesting that autophagy was required for A2E degradation mediated by JS-017. Finally, JS-017 exhibited an improvement in BL-induced retinal damage measured through fundus exami-nation in an in vivo retinal degeneration mouse model. The thickness of the outer nuclear layer and inner/external segments, which was decreased upon exposure to BL irradiation, was also restored upon JS-017 treatment. Altogether, we demonstrated that JS-017 protected human retinal pigment epithelium (RPE) cells from A2E and BL-induced damage by degrading A2E via the activation of autophagy. The results suggest the feasibility of a novel A2E-degrading small molecule as a ther-apeutic agent for retinal degenerative diseases.-
dc.language영어-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.relation.isPartOfBIOCHEMICAL PHARMACOLOGY-
dc.titleA small molecule compound that inhibits blue light-induced retinal damage via activation of autophagy-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000979023400001-
dc.identifier.doi10.1016/j.bcp.2023.115534-
dc.identifier.bibliographicCitationBIOCHEMICAL PHARMACOLOGY, v.211-
dc.description.isOpenAccessN-
dc.identifier.scopusid2-s2.0-85151890271-
dc.citation.titleBIOCHEMICAL PHARMACOLOGY-
dc.citation.volume211-
dc.contributor.affiliatedAuthorShin, Chae Young-
dc.contributor.affiliatedAuthorLee, Sanha-
dc.contributor.affiliatedAuthorFei, Xiang-
dc.contributor.affiliatedAuthorSeo, Seung-Yong-
dc.contributor.affiliatedAuthorJeong, Kwang Won-
dc.type.docTypeArticle-
dc.subject.keywordPlusVACCINIUM-ULIGINOSUM L.-
dc.subject.keywordPlusMACULAR DEGENERATION-
dc.subject.keywordPlusA2E-
dc.subject.keywordPlusPATHOGENESIS-
dc.subject.keywordPlusLUTEIN-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusAMD-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Fei, Xiang photo

Fei, Xiang
Pharmacy (Dept.of Pharmacy)
Read more

Altmetrics

Total Views & Downloads

BROWSE