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Triterpenoids from the leaves of Abies koreana and their biological activities

Authors
Lee, Dong JunHong, Seong-MinYoon, Da HyeHam, Song LimKim, JonghwanKim, Sun YeouChoi, Sang UnKim, Chung SubLee, Kang Ro
Issue Date
Apr-2023
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Abies koreana; Pinaceae; Triterpenoid; Cytotoxic; Anti-neuroinflammation; Neurotrophic
Citation
PHYTOCHEMISTRY, v.208
Journal Title
PHYTOCHEMISTRY
Volume
208
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87694
DOI
10.1016/j.phytochem.2023.113594
ISSN
0031-9422
Abstract
Seven undescribed triterpenoids, abikoranes A-G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example of nor-3,4-seco-17,14-friedo-lanostane triterpenoid. Among the isolates, some compounds showed strong cytotoxic activities against some of four tested cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116) with the values of IC50 0.89-9.62 mu M, inhibited lipopolysaccharide-stimulated nitric oxide production with IC50 values of 11.57-15.16 mu M, and exhibited significant nerve growth factor release effect (192.54 +/- 12.33%) from C6 glioma cells.
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