Neurodegenerative Changes in the Brains of the 5xFAD Alzheimer's Disease Model Mice Investigated by High-Field and High-Resolution Magnetic Resonance Imaging and Multi-Nuclei Magnetic Resonance Spectroscopy
DC Field | Value | Language |
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dc.contributor.author | Yoo, Chi-Hyeon | - |
dc.contributor.author | Kim, Jinho | - |
dc.contributor.author | Baek, Hyeon-Man | - |
dc.contributor.author | Chang, Keun-A | - |
dc.contributor.author | Choe, Bo-Young | - |
dc.date.accessioned | 2023-05-16T00:43:49Z | - |
dc.date.available | 2023-05-16T00:43:49Z | - |
dc.date.created | 2023-05-15 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87707 | - |
dc.description.abstract | This study aimed to investigate morphological and metabolic changes in the brains of 5xFAD mice. Structural magnetic resonance imaging (MRI) and H-1 magnetic resonance spectroscopy (MRS) were obtained in 10- and 14-month-old 5xFAD and wild-type (WT) mice, while P-31 MRS scans were acquired in 11-month-old mice. Significantly reduced gray matter (GM) was identified by voxel-based morphometry (VBM) in the thalamus, hypothalamus, and periaqueductal gray areas of 5xFAD mice compared to WT mice. Significant reductions in N-acetyl aspartate and elevation of myo-Inositol were revealed by the quantification of MRS in the hippocampus of 5xFAD mice, compared to WT. A significant reduction in NeuN-positive cells and elevation of Iba1- and GFAP-positive cells supported this observation. The reduction in phosphomonoester and elevation of phosphodiester was observed in 11-month-old 5xFAD mice, which might imply a sign of disruption in the membrane synthesis. Commonly reported H-1 MRS features were replicated in the hippocampus of 14-month-old 5xFAD mice, and a sign of disruption in the membrane synthesis and elevation of breakdown were revealed in the whole brain of 5xFAD mice by P-31 MRS. GM volume reduction was identified in the thalamus, hypothalamus, and periaqueductal gray areas of 5xFAD mice. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.title | Neurodegenerative Changes in the Brains of the 5xFAD Alzheimer's Disease Model Mice Investigated by High-Field and High-Resolution Magnetic Resonance Imaging and Multi-Nuclei Magnetic Resonance Spectroscopy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000959012900001 | - |
dc.identifier.doi | 10.3390/ijms24065073 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, no.6 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85151107273 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 24 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Kim, Jinho | - |
dc.contributor.affiliatedAuthor | Baek, Hyeon-Man | - |
dc.contributor.affiliatedAuthor | Chang, Keun-A | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | amyloid plaques | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | high-resolution MRI | - |
dc.subject.keywordAuthor | morphologic investigation | - |
dc.subject.keywordAuthor | proton and phosphorus MRS | - |
dc.subject.keywordAuthor | metabolic investigation | - |
dc.subject.keywordPlus | VOXEL-BASED MORPHOMETRY | - |
dc.subject.keywordPlus | MILD COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | CEREBRAL GLUCOSE-UPTAKE | - |
dc.subject.keywordPlus | TRANSGENIC MOUSE MODEL | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | PROTON | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | P-31 | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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