Piezocatalytic 2D WS2 Nanosheets for Ultrasound-Triggered and Mitochondria-Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism-Targeted Chemotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hoang, Quan Truong | - |
dc.contributor.author | Huynh, Kim Anh | - |
dc.contributor.author | Cao, Thuy Giang Nguyen | - |
dc.contributor.author | Kang, Ji Hee | - |
dc.contributor.author | Dang, Xuan Nghia | - |
dc.contributor.author | Ravichandran, Vasanthan | - |
dc.contributor.author | Kang, Han Chang | - |
dc.contributor.author | Lee, Minjong | - |
dc.contributor.author | Kim, Jong-Eun | - |
dc.contributor.author | Ko, Young Tag | - |
dc.contributor.author | Lee, Tae Il | - |
dc.contributor.author | Shim, Min Suk | - |
dc.date.accessioned | 2023-05-16T01:41:13Z | - |
dc.date.available | 2023-05-16T01:41:13Z | - |
dc.date.created | 2023-05-15 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87722 | - |
dc.description.abstract | Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by piezoelectric polarization under an external mechanical force have emerged as an effective platform for cancer therapy. In this study, piezoelectric 2D WS2 nanosheets are functionalized with mitochondria-targeting triphenylphosphonium (TPP) for ultrasound (US)-triggered, mitochondria-targeted piezodynamic cancer therapy. In addition, a glycolysis inhibitor (FX11) that can inhibit cellular energy metabolism is loaded into TPP- and poly(ethylene glycol) (PEG)-conjugated WS2 nanosheet (TPEG-WS2) to potentiate its therapeutic efficacy. Upon US irradiation, the sono-excited electrons and holes generated in the WS2 are efficiently separated by piezoelectric polarization, which subsequently promotes the production of ROS. FX11-loaded TPEG-WS2 (FX11@TPEG-WS2) selectively accumulates in the mitochondria of human breast cancer cells. In addition, FX11@TPEG-WS2 effectively inhibits the production of adenosine triphosphate . Thus, FX11@TPEG-WS2 exhibits outstanding anticancer effects under US irradiation. An in vivo study using tumor-xenograft mice demonstrates that FX11@TPEG-WS2 effectively accumulated in the tumors. Its tumor accumulation is visualized using in vivo computed tomography . Notably, FX11@TPEG-WS2 with US irradiation remarkably suppresses the tumor growth of mice without systemic toxicity. This study demonstrates that the combination of piezodynamic therapy and energy metabolism-targeted chemotherapy using mitochondria-targeting 2D WS2 is a novel strategy for the selective and effective treatment of tumors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | ADVANCED MATERIALS | - |
dc.title | Piezocatalytic 2D WS2 Nanosheets for Ultrasound-Triggered and Mitochondria-Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism-Targeted Chemotherapy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000955863100001 | - |
dc.identifier.doi | 10.1002/adma.202300437 | - |
dc.identifier.bibliographicCitation | ADVANCED MATERIALS, v.35, no.18 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85150616579 | - |
dc.citation.title | ADVANCED MATERIALS | - |
dc.citation.volume | 35 | - |
dc.citation.number | 18 | - |
dc.contributor.affiliatedAuthor | Huynh, Kim Anh | - |
dc.contributor.affiliatedAuthor | Kang, Ji Hee | - |
dc.contributor.affiliatedAuthor | Dang, Xuan Nghia | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.contributor.affiliatedAuthor | Lee, Tae Il | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | glycolysis inhibition | - |
dc.subject.keywordAuthor | mitochondria targeting | - |
dc.subject.keywordAuthor | piezodynamic therapy | - |
dc.subject.keywordAuthor | piezoelectricity | - |
dc.subject.keywordAuthor | WS2 | - |
dc.subject.keywordPlus | LACTATE-DEHYDROGENASE | - |
dc.subject.keywordPlus | THERANOSTIC AGENT | - |
dc.subject.keywordPlus | MONOLAYER MOS2 | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | PIEZOELECTRICITY | - |
dc.subject.keywordPlus | NANOGENERATORS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | LITHIATION | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.