Ultra-sensitive turn-on fluorescent sensor based on β-cyclodextrin-stabilized melamine-derived carbon dots for the highly selective dual-detection of dopamine
DC Field | Value | Language |
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dc.contributor.author | Sangubotla, Roopkumar | - |
dc.contributor.author | Kim, Jongsung | - |
dc.date.accessioned | 2023-05-16T08:40:38Z | - |
dc.date.available | 2023-05-16T08:40:38Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 0272-8842 | - |
dc.identifier.issn | 1873-3956 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87753 | - |
dc.description.abstract | Dopamine (DA) is a critical catecholamine biomolecule with distinct roles, including regulation of learning and memory, in the human brain. The cost-effective, enzyme-free, and highly stabilized fluorescent sensors for neurotransmitters (e.g., DA) are in high demand. In this regard, the development of turn-on fluorescent sensors has gained significant attention in the research field because of their high signal-to-noise ratio, in contrast to turn-off sensors. In this study, we synthesized blue-fluorescent carbon dots (CDs) from melamine and 3-carbox-yphenylboronic acid (3-CPBA) using a solid-state hydrothermal method (MPBCDs) and again modified with beta-cyclodextrin (beta-CD) by simple magnetic stirring (beta-MPBCDs). beta-MPBCDs were characterized by UV-Vis, FT-IR, XPS, HRTEM, SEM, XRD, TGA, Raman, and fluorescence measurements. In contrast to the fluorescence of beta-MPBCDs alone, the fluorescence of beta-MPBCDs combined with guest biomolecule (i.e., pyridoxal: PYL) (beta-MPBCDs-PYL), delivered better fluorescence. The host-guest interaction between beta-CD and PYL biomolecules within the beta-MPBCDs-PYL probe can induce fluorescence sensitivity against DA, which showed a good fluores-cence enhancement against DA at different concentrations (0-320 nM) with a lower detection limit of 56 pM. The intracellular sensing and practicality of the probe for DA was investigated in neuroblastoma (SH-SY5Y) cells and biological samples like human serum and cerebrospinal fluid (CSF). | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Ultra-sensitive turn-on fluorescent sensor based on β-cyclodextrin-stabilized melamine-derived carbon dots for the highly selective dual-detection of dopamine | - |
dc.type | Article | - |
dc.identifier.wosid | 000969219800001 | - |
dc.identifier.doi | 10.1016/j.ceramint.2023.01.225 | - |
dc.identifier.bibliographicCitation | CERAMICS INTERNATIONAL, v.49, no.10, pp 16272 - 16282 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85148752574 | - |
dc.citation.endPage | 16282 | - |
dc.citation.startPage | 16272 | - |
dc.citation.title | CERAMICS INTERNATIONAL | - |
dc.citation.volume | 49 | - |
dc.citation.number | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Carbon dots | - |
dc.subject.keywordAuthor | beta-cyclodextrin | - |
dc.subject.keywordAuthor | Dopamine | - |
dc.subject.keywordAuthor | Biomolecules | - |
dc.subject.keywordAuthor | Turn-on fluorescent sensor | - |
dc.subject.keywordAuthor | Intracellular sensing | - |
dc.subject.keywordPlus | FUNCTIONALIZED GOLD NANOCLUSTERS | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | CITRIC-ACID | - |
dc.subject.keywordPlus | PROBE | - |
dc.subject.keywordPlus | RESONANCE | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Ceramics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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